Research Topic

The Regulatory Roles of Immunological Memory in Pregnancy

About this Research Topic

Immunologic memory is the ability of the immune system to recognize a specific antigen that it has previously encountered and generate a faster and a more appropriate response to it. Common thought is that memory immune cells, such as memory T cells, elicit only a pro-inflammatory response. This is mostly ...

Immunologic memory is the ability of the immune system to recognize a specific antigen that it has previously encountered and generate a faster and a more appropriate response to it. Common thought is that memory immune cells, such as memory T cells, elicit only a pro-inflammatory response. This is mostly seen in their response to foreign bodies such as microbes and transplanted allografts. However, it is also known that immunologic memory can generate a regulatory, anti-inflammatory response which may contribute to tolerance and pregnancy success. The focus of this Research Topic will be on the mechanisms of immunologic memory in reproduction, including exploring novel strategies to translate this understanding into clinical applications to prevent pregnancy complications, and infertility.

Depending on the context, memory immune cells generated upon antigen exposure may exert both beneficial and detrimental functions. They may promote fetal-maternal immune tolerance and may be beneficial for pregnancy. However, in transplantation or pregnancy complications, immune memory cells may elicit pro-inflammatory response, which can be detrimental for the allograft or fetus. In contrast, tolerance is an unwanted response in oncology, with much research devoted to understanding how to inhibit it. These different findings in reproduction, transplantation, and oncology are insightful and postulate new treatment options in the different fields. Imprinting memory before transplantation or conception is proposed as a preventative strategy, making ultimate use of the features of immunologic memory. Understanding the mechanisms in the different contexts, could have great impact on the use of immunosuppression after transplantation. Therefore, the goal of this Research Topic is to further clarify the mechanisms involved in the generation of immune memory before, during and after pregnancy in both healthy and complicated pregnancies.

With this Research Topic we welcome Original Research, Reviews, Clinical Trials, Methods, and Perspectives articles focusing on, but not restricted to:
• Clarifying the regulatory role of immune memory cells in healthy pregnancy and its possible roles in complicated pregnancies
• Clarifying the mechanisms involved in development of immune memory before, during, and after pregnancy
• Identifying the key factors involved in regulation of immune memory during pregnancy
• Defining immune memory cell subpopulations and changes in these cells during healthy and complicated pregnancies
• Presenting novel protocols used to track and identify immune memory cells in in vitro aspects of reproduction and in vivo models of pregnancy


Keywords: Memory Immune Cells, Immune Tolerance, Pregnancy, Immune Regulation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

19 June 2021 Manuscript
17 July 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

19 June 2021 Manuscript
17 July 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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