About this Research Topic
Biological barriers include, but are not limited to, intestinal barrier, nasal barrier, pulmonary barrier, blood brain barrier and skin barrier. As a necessary defence mechanism for living organisms to shield external damage, biological barriers inevitably limit the accumulation of drugs in the lesions and the efficiency of their effects. For example, In the central nervous system, the blood-brain barrier restricts most of the protein medicines from entering the brain. In the respiratory system, the particle deposition mechanism, mucosal barrier, mucus barrier, and clearance mechanism restrict the efficacy of drugs during aerosol treatment of lung diseases. Even in micro-organisms, the biofilms of bacteria have also brought huge challenges to antibiotic research and development. Therefore, overcoming biological barriers is a key goal of drug development. In addition, the body's entire immune mechanism and metabolic absorption system serve as a barrier to protect organisms from external factors, and at the same time put forward higher requirements for drug development.
Nanoparticle-based drug delivery platforms have emerged as suitable vehicles for overcoming pharmacokinetic limitations associated with conventional drug formulations. There are two possible pathways to cross a biological barrier by Nanoparticle-based drugs, one is crossing the barrier via a receptor or adsorptive-mediated transcellular pathway, another is crossing the barrier via paracellular pathways by inducing dysfunction of tight junctions. Furthermore, nanoparticle-based drug can be biodegradable and targetable, it attenuates the side effect of drugs. Therefore, we hypothesis the studies on pharmacokinetics and efficacy of nanoparticle-based drugs overcoming biological barriers will help the development of innovative drug delivery system. These drug delivery platforms can be engineered by both organic and inorganic materials or hybrid, such as bioinspired polymer, bacterial membrane, virus envelope and their modification by chemicals or peptides, as well as other strategies.
There are four main aspects to this Research Topic which will help achieve the goal for breaking through biological barriers for pharmaceutical and treatment purposes. First, we hope to explore the application of nanotechnology, such as targeting drugs delivery system by natural or artificial polymers. Second, we want to explore increasing accumulation of drugs in the brain, tumour and other deep tissues. Third, we want to explore the new strategies for breaking through natural barriers, such as skin, mucous membranes, and cilia. Fourth, we investigate the improvement of physical and chemical properties of the drugs that can improve the penetration of drugs in organs. Overall, by exploring these four primary themes, we hope to obtain improved biodistribution and efficacy of medicines for clinical treatment.
In this Research Topic, we welcome Original Research, Reviews, Mini Reviews, Opinion, Perspective, and Systematic Review articles, including but not limited to the following subjects:
• New bioinspired nano-delivery systems for breaking through biological barriers;
• Use bioinspired nanotechnologies to make breakthroughs in new targets;
• Summaries of the current research on using bionic nanotechnology to break through the biological barrier;
• Prospects for the use of bionic nanotechnology to break through biological barriers.
Nanoparticle-based drug delivery platforms have emerged as suitable vehicles for overcoming pharmacokinetic limitations associated with conventional drug formulations. There are two possible pathways to cross a biological barrier by Nanoparticle-based drugs, one is crossing the barrier via a receptor or adsorptive-mediated transcellular pathway, another is crossing the barrier via paracellular pathways by inducing dysfunction of tight junctions. Furthermore, nanoparticle-based drug can be biodegradable and targetable, it attenuates the side effect of drugs. Therefore, we hypothesis the studies on pharmacokinetics and efficacy of nanoparticle-based drugs overcoming biological barriers will help the development of innovative drug delivery system. These drug delivery platforms can be engineered by both organic and inorganic materials or hybrid, such as bioinspired polymer, bacterial membrane, virus envelope and their modification by chemicals or peptides, as well as other strategies.
There are four main aspects to this Research Topic which will help achieve the goal for breaking through biological barriers for pharmaceutical and treatment purposes. First, we hope to explore the application of nanotechnology, such as targeting drugs delivery system by natural or artificial polymers. Second, we want to explore increasing accumulation of drugs in the brain, tumour and other deep tissues. Third, we want to explore the new strategies for breaking through natural barriers, such as skin, mucous membranes, and cilia. Fourth, we investigate the improvement of physical and chemical properties of the drugs that can improve the penetration of drugs in organs. Overall, by exploring these four primary themes, we hope to obtain improved biodistribution and efficacy of medicines for clinical treatment.
In this Research Topic, we welcome Original Research, Reviews, Mini Reviews, Opinion, Perspective, and Systematic Review articles, including but not limited to the following subjects:
• New bioinspired nano-delivery systems for breaking through biological barriers;
• Use bioinspired nanotechnologies to make breakthroughs in new targets;
• Summaries of the current research on using bionic nanotechnology to break through the biological barrier;
• Prospects for the use of bionic nanotechnology to break through biological barriers.
Keywords: Bioinspired Nanotechnology, Biological Barrier, Drug Delivery System
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