About this Research Topic
Podocytes, the cells with limited ability to replenish and to repair, play a pivotal role in glomerular filtration. In recent years these cells have become the focus for research on pathogenesis of DN as well as other nephropathies. A recent review from the NIH has identified new insights into the pathophysiology, the genetics and the role of the podocytes and some of the important new metabolic pathways such as mTOR or autophagy which may be targeting the podocyte.. Knowledge is emerging about the role of podocyte as a part of immune system and about the role of growth factors and cytokines in regulation of podocyte functions.
The aim of this Research Topic is to highlight recent advances in our understanding of the pathogenesis of kidney pathology and the role of podocytes in this process. Of interest is the reversibility of nephropathic changes and future perspectives. We encourage the contributors to submit mini-reviews, original research articles and review articles .
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