Research Topic

Periradicular Molecular Mediators of Inflammation and Regeneration

About this Research Topic

Periradicular/periapical diseases result in immune response mediated by host-derived, highly orchestrated events at the molecular and cellular levels. If unimpeded, this host immune response would result in tissue breakdown. The periapical tissues, as is the case with other body tissues, attempts to repair or regenerate the previously inflamed tissues under appropriate conditions. Persistent infection and subsequent inflammatory response will influence the inherent regenerative potential of periapical tissues. The trajectory of the immune response in disease as well as healing is undoubtedly linked to complex molecular and cellular events. Molecular signaling and cellular interactions govern the processes of immune and stem cells migration, differentiation and immuno-modulation. The locally derived bioactive molecules, such as cytokines, chemokines, growth factors/receptors, enzymes, released by resident periodontal cells, as well as infiltrating immune cells, and/or necrotic tissues, will have considerable impact on the cellular microenvironment, and subsequent events that characterize disease progression or post-treatment healing. 

This Research Topic aims to collate a set of manuscripts that will focus on the molecular mediators as well as potential biomarkers of periapical inflammation, regeneration and repair using advanced molecular discovery techniques to further our understanding on periapical disease progression, post-treatment healing characteristics, regenerative endodontic procedures, root resorption etc. Manuscripts submitted under this Research Topic may include clinical studies, as well as in vitro and in vivo functional characterization and mechanistic studies that aim to elucidate the molecular basis of periapical tissues in homeostasis and disease. Both original research and review articles that have a unique standpoint on the immunological aspects of periradicular tissues are encouraged for submission.


Keywords: Periradicular, Molecular Mediators, Inflammation, Regeneration, Dental


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Periradicular/periapical diseases result in immune response mediated by host-derived, highly orchestrated events at the molecular and cellular levels. If unimpeded, this host immune response would result in tissue breakdown. The periapical tissues, as is the case with other body tissues, attempts to repair or regenerate the previously inflamed tissues under appropriate conditions. Persistent infection and subsequent inflammatory response will influence the inherent regenerative potential of periapical tissues. The trajectory of the immune response in disease as well as healing is undoubtedly linked to complex molecular and cellular events. Molecular signaling and cellular interactions govern the processes of immune and stem cells migration, differentiation and immuno-modulation. The locally derived bioactive molecules, such as cytokines, chemokines, growth factors/receptors, enzymes, released by resident periodontal cells, as well as infiltrating immune cells, and/or necrotic tissues, will have considerable impact on the cellular microenvironment, and subsequent events that characterize disease progression or post-treatment healing. 

This Research Topic aims to collate a set of manuscripts that will focus on the molecular mediators as well as potential biomarkers of periapical inflammation, regeneration and repair using advanced molecular discovery techniques to further our understanding on periapical disease progression, post-treatment healing characteristics, regenerative endodontic procedures, root resorption etc. Manuscripts submitted under this Research Topic may include clinical studies, as well as in vitro and in vivo functional characterization and mechanistic studies that aim to elucidate the molecular basis of periapical tissues in homeostasis and disease. Both original research and review articles that have a unique standpoint on the immunological aspects of periradicular tissues are encouraged for submission.


Keywords: Periradicular, Molecular Mediators, Inflammation, Regeneration, Dental


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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