Research Topic

Oral Senescence: From Molecular Biology to Clinical Research

About this Research Topic

The oral cavity is a complex system and the point of entry of the digestive system. Many different organs and tissues interact and function together under the constant challenge of microbes, physical and chemical stimuli. The system’s capacity to cope with these various challenges depends in an orderly and regulated response, one that is coordinated at the molecular, cellular and tissular level.

For the last century we have witnessed a worldwide trend for increased life expectancy, and the perspective of an inverted demographic pyramid is on our near horizon. Population’s aging will have an impact in human health and health services. A deeper understanding of the aging process is necessary to provide quality care to an ever-growing cohort of elder patients.

The process of aging or biological senescence disrupts and alters the oral cavity’s capacity to respond and adapt to changes of the environment, giving rise to increase frailty and proclivity to disease. Although natural, biological senescence results in functional and architectural tissue changes that fundamentally modify the adaptive capacity of the system, lowering the threshold necessary to cause harm.

The objective of this Research Topic is to gather in a single source high quality and up to date research regarding oral senescence from different and mutually complementary perspectives, ranging from molecular biology to clinical research.

We would like to welcome contributions to this topic in the form of Original articles, Reviews or Mini-Reviews covering the following research areas:

1) Updates in structural and functional changes of oral tissues during aging;
2) Molecular analysis and characterization of aged oral cells;
3) Repair and defense of oral tissues during aging;
4) Clinical characterization of the aging process in oral tissues;
5) Therapeutic interventions and response to treatment in elder adults;
6) Proof-of-principle research on molecular therapeutics in aged oral tissues;
7) Molecular targets to characterize oral tissues;
8) Secreted molecular targets in oral fluids used to characterize aging;
9) Oral microbiome changes during aging.


Keywords: Aging, Senescence, Molecular Targets, Oral Tissue, Tissue Repair


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The oral cavity is a complex system and the point of entry of the digestive system. Many different organs and tissues interact and function together under the constant challenge of microbes, physical and chemical stimuli. The system’s capacity to cope with these various challenges depends in an orderly and regulated response, one that is coordinated at the molecular, cellular and tissular level.

For the last century we have witnessed a worldwide trend for increased life expectancy, and the perspective of an inverted demographic pyramid is on our near horizon. Population’s aging will have an impact in human health and health services. A deeper understanding of the aging process is necessary to provide quality care to an ever-growing cohort of elder patients.

The process of aging or biological senescence disrupts and alters the oral cavity’s capacity to respond and adapt to changes of the environment, giving rise to increase frailty and proclivity to disease. Although natural, biological senescence results in functional and architectural tissue changes that fundamentally modify the adaptive capacity of the system, lowering the threshold necessary to cause harm.

The objective of this Research Topic is to gather in a single source high quality and up to date research regarding oral senescence from different and mutually complementary perspectives, ranging from molecular biology to clinical research.

We would like to welcome contributions to this topic in the form of Original articles, Reviews or Mini-Reviews covering the following research areas:

1) Updates in structural and functional changes of oral tissues during aging;
2) Molecular analysis and characterization of aged oral cells;
3) Repair and defense of oral tissues during aging;
4) Clinical characterization of the aging process in oral tissues;
5) Therapeutic interventions and response to treatment in elder adults;
6) Proof-of-principle research on molecular therapeutics in aged oral tissues;
7) Molecular targets to characterize oral tissues;
8) Secreted molecular targets in oral fluids used to characterize aging;
9) Oral microbiome changes during aging.


Keywords: Aging, Senescence, Molecular Targets, Oral Tissue, Tissue Repair


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 August 2021 Abstract
30 November 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 August 2021 Abstract
30 November 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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