Research Topic

Substance Use Disorders and the Brain

About this Research Topic

Substance use disorders (SUDs) are a global public health concern. Persons with SUDs often suffer from cognitive abnormalities and mental health issues that might predispose them to problematic drug/alcohol use, increase the likelihood that they develop a SUD, and/or serve as barriers to successful treatment.

The underpinnings of several aspects of SUDs and cognitive/emotional issues share common neural substrates. As such, experimental and clinical research on SUDs and the brain is important to address the global substance use crisis; both in increasing our understanding of the mechanisms responsible for SUDs, and in understanding how to identify and overcome barriers to treatment.

This Research Topic is focused on brain-based research in real-world populations of persons with SUDs. Research that takes place in a clinical environment, with clinical populations, and/or is related to cognitive and emotional processes that apply to persons with SUDs is highly encouraged.

Specific areas of interest include:

- The role of the prefrontal cortex in SUDs;
- Network connectivity in SUD populations;
- Biological correlates of cognition, emotion, and stress in SUDs;
- Neuroimaging to predict treatment outcomes.

Research that utilizes portable neuroimaging devices such as functional near-infrared spectroscopy or electroencephalography is highly encouraged.

This Research Topic will accept all article types, including Original Investigations, Systematic, Narrative, and/or Mini Reviews, Methods, and Case Reports. In general, articles should fall into the broad theme of brain-based research in persons with SUDs.


Keywords: Substance Use Disorder, Brain, Cortex, Addiction, Neuroimaging


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Substance use disorders (SUDs) are a global public health concern. Persons with SUDs often suffer from cognitive abnormalities and mental health issues that might predispose them to problematic drug/alcohol use, increase the likelihood that they develop a SUD, and/or serve as barriers to successful treatment.

The underpinnings of several aspects of SUDs and cognitive/emotional issues share common neural substrates. As such, experimental and clinical research on SUDs and the brain is important to address the global substance use crisis; both in increasing our understanding of the mechanisms responsible for SUDs, and in understanding how to identify and overcome barriers to treatment.

This Research Topic is focused on brain-based research in real-world populations of persons with SUDs. Research that takes place in a clinical environment, with clinical populations, and/or is related to cognitive and emotional processes that apply to persons with SUDs is highly encouraged.

Specific areas of interest include:

- The role of the prefrontal cortex in SUDs;
- Network connectivity in SUD populations;
- Biological correlates of cognition, emotion, and stress in SUDs;
- Neuroimaging to predict treatment outcomes.

Research that utilizes portable neuroimaging devices such as functional near-infrared spectroscopy or electroencephalography is highly encouraged.

This Research Topic will accept all article types, including Original Investigations, Systematic, Narrative, and/or Mini Reviews, Methods, and Case Reports. In general, articles should fall into the broad theme of brain-based research in persons with SUDs.


Keywords: Substance Use Disorder, Brain, Cortex, Addiction, Neuroimaging


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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