About this Research Topic
Most biological cells are constantly exposed to different fluid environments. Examples include blood cells in blood flow, cell manipulation in microfluidic devices, bacteria propulsion within a fluid medium, and multicellular assemblies such as tissues and biofilms under biological and environmental flows. The common aspect for all these systems is an intricate coupling between cellular behavior and fluid flow. In particular, cells in fluid flow are necessarily subjected to fluid-flow stresses, which can affect the multicellular organization and individual cell dynamics, induce deformation, facilitate cell motility, and be used for probing cell mechanical properties. This area of research has attracted considerable scientific attention due to many unresolved fundamental questions as well as possible practical applications. Furthermore, it encompasses a number of scientific fields, including soft matter, cell mechanics, biophysics, fluid dynamics, and bioengineering.
The goal of this Research Topic is to collect recent advances on the behaviour of biological cells in fluid flows and to discuss different interdisciplinary aspects in this research area. Even though biological cells and multicellular assemblies generally exhibit a very complex behaviour in fluid flow, this research direction has great opportunities for finding novel physical mechanisms and for using such systems in many technological and biomedical applications.
We invite experimental, simulation, and theoretical contributions at the interface between cellular behaviour and fluid flow. Original Research, Review, Mini Review, and Perspective articles are welcome.
In particular, we expect contributions from the following research areas:
• Response and deformation of cell and multicellular aggregates in fluid flow
• Cell manipulation and sorting in microfluidics
• Cell motility in a fluid environment
• Multicellular suspensions
• Single-cell and multicellular adhesion inflow
• Fluid flows generated by cells.
This is not an exhaustive list and other contributions which include the interplay between fluid flow and cell behaviour will also be considered.
Keywords: Cell mechanics, flow stresses, microfluidics, motility, cell deformation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.