About this Research Topic
With an ever-growing requirement of highly sensitive detection of biomarkers, either specific to diseases or establishing their role in the body’s homeostasis mechanism, the evolving technological landscape governs that domain. Technologies, such as Mesoscale Discovery (MSD), Quanterix Simoa, or Quantum Diamond Technologies platforms, have found unique ways around conventional approaches to enhance sensitivities. It is interesting that these technologies in one way or the other integrate nano-enabled tools. For example, MSD incorporates ruthenium nanocomplexes to generate electrochemiluminescence and Quanterix employs magnetic nano/microparticles. Having materials in confined nano spaces allow for several physical phenomena that act either by stabilizing the signal (FRET etc.), or producing a higher collective signal for each binding event thus making detection more sensitive. Similarly, Luminex technology employs colored nano/micro beads at the foundation of their technology allowing for multiplex capabilities. On these lines of improving sensitivities, using nanomaterials for enhancing/stabilizing biomolecule activity becomes another crucial aspect as stabilized molecules will demonstrate better activity thus resulting in improved sensitivity. Molecularly imprinted nanomaterial as a substitute for biomolecules is one such example.
The challenge, however, lies with developing technologies that could allow biologists to establish detecting biomolecules with unprecedented sensitivities given these markers exist in unknown baseline amounts (the more sensitive technology becomes the lower we are able to establish their presence which currently rests at single-digit fg/mL levels).
In this Research Topic, we envision to publish high-quality research directed at developing nanotechnology-based tools for applications in detection. Recent advances in the applications of graphene, carbon nanotubes, nanoparticles, and/or other advanced nanomaterials at the interface of biology will allow an improvement of the current state-of-the-art. In particular, research on enhancing detection sensitivity, biomolecule stabilizing, creating nanotools that have great commercial potential are few thrust areas of this call; however, all domains of nanomaterial applications are encouraged.
We welcome research on, but not restricted to, the following research areas when utilizing nanomaterials:
· Biomolecule detection platforms
· Sensitive detection methods
· Unconventional approaches
· Biomolecular analysis
· Bioanalytical methods
· Separation approaches improving separation specificity
· In-vitro diagnostics
Keywords: Immuno bio analysis, sensitive detection, analytical, in-vitro, separation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.