About this Research Topic
Various innovations in the niche of nanobiotechnology and avant-garde nano-biomaterials have catapulted nano-bioengineering-research to newer heights, enabling an easier, prompt and comprehensive unmasking of the complexities and the health status in various biological systems as well as the discovery of feasible solutions for a gamut of biological complications. As an exemplary evidence, nanostructured biopolymeric scaffolds and nano-biocomposites offer a much closer structure-function mimic to the native tissues than traditional counterparts, attesting the former’s immense potential in tissue engineering and regenerative medicine. By the same token, nano-scaled agents for imaging and therapeutic applications (bioactive cargoes- delivery) are endowed with numerous advantages over their counterparts, including excellent tunability (e.g., optical and magnetic attributes), high stability (e.g., counteracting photobleaching), availability of a wide gamut of functionalization-strategies; multimodality, high sensitivity as well as selectivity, possibility of stimuli-responsive and on-demand targeted delivery etc. Thus, nano-biomaterials offer numerous possible explorable opportunities in the biomedical field.
Albeit, the number of publications and patents pertaining to nano-biomaterials and their applications has escalated tremendously over the last few years, a number of pertinent issues need deeper delving. For example, the use of biocompatible and biodegradable nanofibrous scaffolds may often be viewed as apt in ensuring sustainable tissue-engineering, however, the successful design (ensuring the neotissues’ sufficient thickness and size, vascularity and innervation) and characterization (particularly the biomechanical attributes, using standardized methodology) of the nano-biomaterials to replicate the tissue-niche/ microenvironment with clinically driven approaches are of paramount importance. Similarly, one may easily perceive that nano-biomaterials can have real impact in improving the delivery of therapeutic agents/ drugs through multiple modes including augmented drug loading, heightened affinity to target cells, and precise spatiotemporal control of drug release. However, aspects such as molecular understanding of the trafficking of the nanocarriers into the target cells as well as the toxicity and immunomodulatory effects and the clearance of the nanomaterials still remain elusive. The proposed special issue aims to include manuscripts, addressing such and allied questions in the realm.
This special issue seeks manuscripts (original research, review, and mini-reviews articles) that are expected to substantially increase our comprehension, ranging from the structure-process-property accord of nano-biomaterials under in vivo, in vitro, and in silico ambiance to their biomedical applications in the realms of diagnosis, therapy, and bioimaging. The innovations, new directions, practical snags, and concerns, pertaining to the use of nano-biomaterials in the biomedical spectrum shall be the prime focus of the proposed article collection. We invite researchers to submit papers on, but not restricted to, the following topics:
· Nano-biomaterials: bioinspired designs (e.g., virus based nanomaterials for immunotherapy) and biomimetics
· Surface modification, nano-topography, modelling and simulation of nano-biomaterials and devices
· Nano-biomaterials for tissue engineering and regenerative medicine
· 3D/4D bio-printed nano-biomaterials
· Devices based on nano-biomaterials
· Nano-biomaterials based non-invasive bioimaging technology
· Stimuli responsive nano-biomaterials and biomedical applications (e.g., magnetic hyperthermia)
· Targeted and triggered delivery of bioactive therapeutic agents (anti-cancer drugs) and the delivery of immune-modulating agents
· Biomedically relevant catalytic nanomaterials (nanozymes)
· Toxicity, degradability, and life cycle assessment of nano-biomaterials
· Neoteric approaches to understand events at the nano-bio interface
Keywords: Transcending new frontiers in diagnosis, imaging, and therapy with nanobiomaterials
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.