About this Research Topic
Wnt/β-catenin signaling is an evolutionarily conserved pathway with key and essential roles in embryogenesis and adult tissue regeneration and repair. It plays a pivotal role during tooth development, and regulates tooth morphogenesis at various stages. It is indispensable for the initiation of primary and replacement teeth, and mutations in various components of the Wnt/β-catenin signaling pathway have been identified in syndromic and non-syndromic tooth agenesis.
Wnt/β-catenin signaling has also been implicated in reparative dentinogenesis, governing activation and proliferation of resident progenitor cells in dental pulp, and their recruitment and migration to the site of injury. Wnt/β-catenin signaling also regulates differentiation of these resident progenitors into cells secreting the reparative dentin.
The objective of the present Research Topic is to provide an updated vision on dental biomaterials research, focusing on their biological properties and interactions to act as evidence for their potential use in vital pulp treatment procedures.
This Research Topic aims to collate a set of manuscripts that will focus on the roles of Wnt/β-catenin signaling in tooth development and regeneration of the dentin-pulp complex. Papers may include animal models, cell cultures, functional studies, or techniques using other latest advances in molecular biology that aim to elucidate roles of the Wnt/β-catenin signaling in tooth development and repair.
Keywords: Tooth development, Tooth abnormalities, Regeneration, Adult stem cell, Reparative dentinogenesis, reactionary dentinogenesis
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