Research Topic

Wnt Signaling in Tooth Development and Repair of Dentin-Pulp Complex

About this Research Topic

Wnt/β-catenin signaling is an evolutionarily conserved pathway with key and essential roles in embryogenesis and adult tissue regeneration and repair. It plays a pivotal role during tooth development, and regulates tooth morphogenesis at various stages. It is indispensable for the initiation of primary and replacement teeth, and mutations in various components of the Wnt/β-catenin signaling pathway have been identified in syndromic and non-syndromic tooth agenesis.

Wnt/β-catenin signaling has also been implicated in reparative dentinogenesis, governing activation and proliferation of resident progenitor cells in dental pulp, and their recruitment and migration to the site of injury. Wnt/β-catenin signaling also regulates differentiation of these resident progenitors into cells secreting the reparative dentin.

The objective of the present Research Topic is to provide an updated vision on dental biomaterials research, focusing on their biological properties and interactions to act as evidence for their potential use in vital pulp treatment procedures.

This Research Topic aims to collate a set of manuscripts that will focus on the roles of Wnt/β-catenin signaling in tooth development and regeneration of the dentin-pulp complex. Papers may include animal models, cell cultures, functional studies, or techniques using other latest advances in molecular biology that aim to elucidate roles of the Wnt/β-catenin signaling in tooth development and repair.


Keywords: Tooth development, Tooth abnormalities, Regeneration, Adult stem cell, Reparative dentinogenesis, reactionary dentinogenesis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Wnt/β-catenin signaling is an evolutionarily conserved pathway with key and essential roles in embryogenesis and adult tissue regeneration and repair. It plays a pivotal role during tooth development, and regulates tooth morphogenesis at various stages. It is indispensable for the initiation of primary and replacement teeth, and mutations in various components of the Wnt/β-catenin signaling pathway have been identified in syndromic and non-syndromic tooth agenesis.

Wnt/β-catenin signaling has also been implicated in reparative dentinogenesis, governing activation and proliferation of resident progenitor cells in dental pulp, and their recruitment and migration to the site of injury. Wnt/β-catenin signaling also regulates differentiation of these resident progenitors into cells secreting the reparative dentin.

The objective of the present Research Topic is to provide an updated vision on dental biomaterials research, focusing on their biological properties and interactions to act as evidence for their potential use in vital pulp treatment procedures.

This Research Topic aims to collate a set of manuscripts that will focus on the roles of Wnt/β-catenin signaling in tooth development and regeneration of the dentin-pulp complex. Papers may include animal models, cell cultures, functional studies, or techniques using other latest advances in molecular biology that aim to elucidate roles of the Wnt/β-catenin signaling in tooth development and repair.


Keywords: Tooth development, Tooth abnormalities, Regeneration, Adult stem cell, Reparative dentinogenesis, reactionary dentinogenesis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

13 July 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

13 July 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..