Research Topic

Kinase Dysregulation in Alzheimer's Disease

  • Submission closed.

About this Research Topic

Alzheimer's disease is a neurodegenerative disease that causes dementia. The pathological hallmarks of the disease are substantial neuronal cell loss, amyloid plaques consisting of amyloid peptide and intracellular neurofibrillary tangles containing hyperphosphorylated tau. Further, post-mortem analyses have ...

Alzheimer's disease is a neurodegenerative disease that causes dementia. The pathological hallmarks of the disease are substantial neuronal cell loss, amyloid plaques consisting of amyloid peptide and intracellular neurofibrillary tangles containing hyperphosphorylated tau. Further, post-mortem analyses have established that synapse loss precedes neuronal cell loss and correlates best with impaired memory. It is thought that soluble oligomeric amyloid peptides induce aberrant signalling that impairs synaptic function and neuronal survival. This aberrant singalling includes hyperphosphorylation of the cytoskeletal protein tau, a prerequisite for tangle formation. This indicates that protein kinases are dysregulated in Alzheimer's disease. Recently, a number of kinase dysregulations have been considered to occur in Alzheimer's disease. Since understanding of these kinase dysregulations could be a critical step for preventing neurodegeneration, we would like to discuss this research topic in detail.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top