About this Research Topic
Precise diagnosis and evaluation of neurodegenerative disorders are vital for precise treatment. Although neuropathologic techniques are considered as the gold standard, these applications are often not feasible in the clinic. To date, the diagnosis and evaluation of neurodegenerative disorders mainly depend on clinical manifestations and rating scale assessment. Such approaches have obvious disadvantages. First, it relies on the experience of the physicians. Second, such diagnosis and evaluation are subjective, which usually result in low accuracy and consistency. Thus, an objective, precise and feasible approach is urgently needed for the clinical diagnosis and evaluation of neurodegenerative disorders.
MRI has been regarded as a promising technique in this field, with the advantages of multiparameter and non-invasion. Multiple functional MRI techniques have been approved to be helpful in the diagnosis and evaluation of neurodegenerative disorders. For example, quantitative susceptibility mapping plays important role in quantifying tissue susceptibility and contributes to seeking imaging biomarkers in neurodegenerative disease. However, most of these techniques are not feasible and suitable for widely applying in the clinic, as the high demand for the MR scanners, scan time, and post-processing software etc.
The MRI, particularly conventional MRI, sequences, which are often based on the observation of readers, can only provide limited information in the diagnosis and evaluation of neurodegenerative disorders. However, radiomics, a technique extracting quantitative characteristics automatically from medical images, can deeply analyze the data rather than just simply observing pictures. It may help us to gain more detailed information from conventional MRI images. The application of conventional MRI-based radiomics in the diagnosis and evaluation of neurodegenerative disorders is still needed to be further investigated.
In this Research Topic, we will focus on the role of MRI-based radiomics in the diagnosis and evaluation of neurodegenerative disorders. We call for all original research articles, reviews, short essays, and perspectives for this specialized research topic. This Research Topic will include, but not limited to, the following themes:
1. Developing new algorithms or optimizing existing MRI-based radiomics for diagnosis and evaluation of neurodegenerative disorders.
2. Investigating the applications of radiomics with various MRI sequences, including T1WI, T2WI, T2-FLAIR, DWI and T2*WI, for diagnosis and evaluation of neurodegenerative disorders.
3. Exploring clinical translational potentials of MRI-based radiomics in the diagnosis and evaluation of Parkinson's disease, Alzheimer's disease, multiple system atrophy, and other neurodegenerative disorders.
Keywords: MRI, Radiomics, Diagnosis, Evaluation, Neurodegenerative Disorders
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