Research Topic

Single-cell sequencing for brain development, aging and diseases

About this Research Topic

Single-cell sequencing has emerged as a powerful tool for investigating cell states and functions at the single-cell level. It has greatly revolutionized transcriptomic and epigenomic studies in many life science research fields, including neurobiology and developmental biology. With the fast development of both experimental platforms and bioinformatics approaches over the past decade, single-cell sequencing is becoming economically feasible and experimentally practical for many biomedical laboratories.



The recent application of single-cell sequencing methods to neuroscience has led to a number of exciting discoveries, including classifying neuronal types, discovering new cell types, identifying critical genes underlying brain development and aging and so on. Our research topic here will focus on the combination of single-cell sequencing, including genomics, transcriptomics and epigenomics, and functional exploration of brain development and brain aging and diseases. We welcome original research articles, clinical research articles, as well as review papers related to our topic. Authors will be offered the opportunity to present highlights of their work on an online video platform.


Keywords: single-cell sequencing, neuroscience, neurodevelopment, brain aging


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Single-cell sequencing has emerged as a powerful tool for investigating cell states and functions at the single-cell level. It has greatly revolutionized transcriptomic and epigenomic studies in many life science research fields, including neurobiology and developmental biology. With the fast development of both experimental platforms and bioinformatics approaches over the past decade, single-cell sequencing is becoming economically feasible and experimentally practical for many biomedical laboratories.



The recent application of single-cell sequencing methods to neuroscience has led to a number of exciting discoveries, including classifying neuronal types, discovering new cell types, identifying critical genes underlying brain development and aging and so on. Our research topic here will focus on the combination of single-cell sequencing, including genomics, transcriptomics and epigenomics, and functional exploration of brain development and brain aging and diseases. We welcome original research articles, clinical research articles, as well as review papers related to our topic. Authors will be offered the opportunity to present highlights of their work on an online video platform.


Keywords: single-cell sequencing, neuroscience, neurodevelopment, brain aging


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

15 July 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

15 July 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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