About this Research Topic
Background: Staphylococcus aureus is a major pathogen causing both community-acquired as well as nosocomial infections. S. aureus is equipped with an arsenal of virulence factors, enabling them to rapidly adapt to various conditions to persist and evade the immune system. In addition, S. aureus is able to develop/acquire multiple antibiotic resistances, complicating and limiting treatment options. Nasopharyngeal colonization is the main reservoir of S. aureus in the human body and is considered as one of the significant risk factors for the acquisition of S. aureus infections.
Next-generation sequencing (NGS) has revolutionized the field of microbiology. Currently, NGS is primarily utilized for molecular typing purposes and outbreak analysis, thus not using the full potential of this technology. Proteomic and transcriptomic analysis may help elucidate the host-pathogen interaction and S. aureus physiology, especially the transition from colonization to infection.
Goal: To gain a better knowledge using OMICs technology of the adaptive/evolutionary changes influencing virulence and antimicrobial resistance that drive the success of S. aureus.
Scope: Collect primarily Original Research articles (but Reviews and Mini-Reviews are also accepted). The articles should focus on the virulence and antimicrobial resistance of S. aureus, and can include immunological and epidemiological studies.
Details for Authors: We are interested in original work with an emphasis on microbiological and immunological studies of S. aureus virulence and antimicrobial resistance using NGS/Omics technology. Additionally, genomic analysis of evolutionary events and dissemination of introduced clones are also of interest.
The following themes are of interest for this special issue:
• Studies on antimicrobial resistance/virulence mechanisms using NGS, including those of evolution, adaptation, heterogeneity in acute and chronic infections (focus on the bacterial side).
• Immunological studies on S. aureus infection and colonization using OMICS approachs (e.g. proteomics, transcriptomics) with focus on either host, bacteria, or both.
• Epidemiological and phylogenomic studies on S. aureus focusing on evolution/adaptation
• In silico antimicrobial resistance-prediction (multi-level and integrative analysis, as well as other innovative approachs)
• Interaction with other bacteria in a polymicrobial host/non-host environment
Keywords: Omics, Staphylococcus aureus, Virulence, Resistance, NGS
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.