About this Research Topic
Converging experimental approaches across multiple species, including combinations of electrophysiological, pharmacological and optogenetic targeting, are allowing for progressively refined accounts of the neurobiological bases of diverse cognitive functions. As the techniques for mapping, as well as altering, local neurochemical environments advance, translational modeling of human clinical findings becomes increasingly sophisticated, particularly when coupled to genotypic analyses. Non-invasive imaging provided by MR, and microPET, as well as microSPECT and microCT, are central for much of this work, serving both to guide direct manipulation of discrete neuronal populations and to measure the functional changes elicited by such manipulations. Using these various imaging methods requires thorough analysis, however, as what you see is not always what you get.
This research topic, for the Frontiers in Integrative Neuroscience series, is intended to address (i) mechanisms for optimizing local targeting, based on MR, microPET, microSPECT and microCT imaging, (ii) emerging work in the field of molecular MRI, for visualizing elements of signal transduction in vivo, (iii) use of non-invasive imaging to examine structural and functional profiles associated with particular genetic polymorphisms (5HTT, DAT, etc.), and (iv) advances in evaluating data derived from fMRI in the context of electrophysiological data, derived from surface microECoG arrays, laminar electrodes, and chronic microwire arrays. Additionally, studies assessing how reliably non-invasive imaging methods delineate regions of local tissue trauma, both experimentally induced as well as due to neuropathology, are welcome. Collectively, these types of approaches will help elucidate complex clinical conditions, including stroke, TBI, progressive neurodegenerative disorders, and drug addiction. Authors are encouraged to submit original and review articles, as well as methods papers describing relevant state of the art techniques in both rodent and NHP model systems.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.