Research Topic

Techniques and translations: MR- and microPET-­based targeting and assessments

About this Research Topic

Converging experimental approaches across multiple species, including combinations of electrophysiological, pharmacological and optogenetic targeting, are allowing for progressively refined accounts of the neurobiological bases of diverse cognitive functions. As the techniques for mapping, as well as ...

Converging experimental approaches across multiple species, including combinations of electrophysiological, pharmacological and optogenetic targeting, are allowing for progressively refined accounts of the neurobiological bases of diverse cognitive functions. As the techniques for mapping, as well as altering, local neurochemical environments advance, translational modeling of human clinical findings becomes increasingly sophisticated, particularly when coupled to genotypic analyses. Non-invasive imaging provided by MR, and microPET, as well as microSPECT and microCT, are central for much of this work, serving both to guide direct manipulation of discrete neuronal populations and to measure the functional changes elicited by such manipulations. Using these various imaging methods requires thorough analysis, however, as what you see is not always what you get.

This research topic, for the Frontiers in Integrative Neuroscience series, is intended to address (i) mechanisms for optimizing local targeting, based on MR, microPET, microSPECT and microCT imaging, (ii) emerging work in the field of molecular MRI, for visualizing elements of signal transduction in vivo, (iii) use of non-invasive imaging to examine structural and functional profiles associated with particular genetic polymorphisms (5HTT, DAT, etc.), and (iv) advances in evaluating data derived from fMRI in the context of electrophysiological data, derived from surface microECoG arrays, laminar electrodes, and chronic microwire arrays. Additionally, studies assessing how reliably non-invasive imaging methods delineate regions of local tissue trauma, both experimentally induced as well as due to neuropathology, are welcome. Collectively, these types of approaches will help elucidate complex clinical conditions, including stroke, TBI, progressive neurodegenerative disorders, and drug addiction. Authors are encouraged to submit original and review articles, as well as methods papers describing relevant state of the art techniques in both rodent and NHP model systems.


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Submission Deadlines

20 May 2018 Abstract
15 November 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

20 May 2018 Abstract
15 November 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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