Research Topic

Intestinal-level Bioactivities of Phytochemicals

About this Research Topic

Gastrointestinal health is a key determinant of overall human health. Especially in case of non-communicable chronic metabolic diseases like diabetes, non-alcoholic steatohepatitis, cardiometabolic complications, and obesity, intestine-specific events such as alterations in gut microbial population, diversity and metabolic functions; mucosal inflammation; and gut barrier dysfunction is associated with disease pathogenesis. In recent years, it has also been evident that gut-to-systemic endotoxin translocation triggers a persistent ‘low-grade’ systemic inflammation which underlines chronic diseases. Alterations in host-microbial interactions at the intestine also results in dynamic shifts in luminal metabolomic profile which could potentially serve as a marker of metabolic disease. Therefore, improvements of intestinal health by targeting gastrointestinal 3-Ms (i.e. Metabolism, Microbiome, Metabolome) to maintain immunometabolic homeostasis is a lucrative strategy against chronic diseases.

Obesity-associated chronic metabolic diseases are collectively one of the greatest contributors of mortality globally. In the absence of validated therapeutic strategy, dietary phytochemicals are an emerging alternative prophylactic strategy to mitigate metabolic disease. While there has been a plethora of evidence demonstrating metabolic health benefits of phytochemicals, the intestinal-level mode of action of phytochemicals remains critically underexplored. For example, how phytochemicals affect host-microbe reciprocal interactions? How gut microbe-dependent phytochemical metabolism effects bioactivities? What are the phytochemical sensitive intestinal cognate receptors present at the intestine? How dietary phytochemicals can induce changes in luminal global metabolome to exert health benefits? How parent phytochemicals and their microbial metabolites helps in maintaining gut barrier integrity and limit mucosal inflammation? In the light of the dynamic 3-M interactions, these are important questions to be answered for the development of effective phytochemical-based alternative strategy against chronic diseases.

The research topic “Intestinal-level Bioactivities of Phytochemicals” welcomes manuscripts which specifically deals with health beneficial effects of purified phytochemicals or chemically defined phytoextracts through intestinal-level bioactivities. Authors are encouraged to submit original experimental articles, comprehensive reviews, and short communications associated with this special issue. In particular, the topics of interest include, but are not limited to:
• Pre-clinical and clinical studies demonstrating benefits of phytochemicals on gut microbiome, mucosal inflammation and gut barrier dysfunction
• Proof of concept studies demonstrating phytochemical-mediated improvements of intestinal health mitigates chronic diseases
• Phytochemical-mediated favorable modulation of intestinal global metabolome
• Gut microbiome-dependent metabolism of phytochemicals to improve systemic bioavailability
• Beneficial effects of phytochemicals on intestinal cognate receptors.


Keywords: Gut barrier dysfunction, Gut-liver axis, Microbiome, Mucosal inflammation, Phytochemicals


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Gastrointestinal health is a key determinant of overall human health. Especially in case of non-communicable chronic metabolic diseases like diabetes, non-alcoholic steatohepatitis, cardiometabolic complications, and obesity, intestine-specific events such as alterations in gut microbial population, diversity and metabolic functions; mucosal inflammation; and gut barrier dysfunction is associated with disease pathogenesis. In recent years, it has also been evident that gut-to-systemic endotoxin translocation triggers a persistent ‘low-grade’ systemic inflammation which underlines chronic diseases. Alterations in host-microbial interactions at the intestine also results in dynamic shifts in luminal metabolomic profile which could potentially serve as a marker of metabolic disease. Therefore, improvements of intestinal health by targeting gastrointestinal 3-Ms (i.e. Metabolism, Microbiome, Metabolome) to maintain immunometabolic homeostasis is a lucrative strategy against chronic diseases.

Obesity-associated chronic metabolic diseases are collectively one of the greatest contributors of mortality globally. In the absence of validated therapeutic strategy, dietary phytochemicals are an emerging alternative prophylactic strategy to mitigate metabolic disease. While there has been a plethora of evidence demonstrating metabolic health benefits of phytochemicals, the intestinal-level mode of action of phytochemicals remains critically underexplored. For example, how phytochemicals affect host-microbe reciprocal interactions? How gut microbe-dependent phytochemical metabolism effects bioactivities? What are the phytochemical sensitive intestinal cognate receptors present at the intestine? How dietary phytochemicals can induce changes in luminal global metabolome to exert health benefits? How parent phytochemicals and their microbial metabolites helps in maintaining gut barrier integrity and limit mucosal inflammation? In the light of the dynamic 3-M interactions, these are important questions to be answered for the development of effective phytochemical-based alternative strategy against chronic diseases.

The research topic “Intestinal-level Bioactivities of Phytochemicals” welcomes manuscripts which specifically deals with health beneficial effects of purified phytochemicals or chemically defined phytoextracts through intestinal-level bioactivities. Authors are encouraged to submit original experimental articles, comprehensive reviews, and short communications associated with this special issue. In particular, the topics of interest include, but are not limited to:
• Pre-clinical and clinical studies demonstrating benefits of phytochemicals on gut microbiome, mucosal inflammation and gut barrier dysfunction
• Proof of concept studies demonstrating phytochemical-mediated improvements of intestinal health mitigates chronic diseases
• Phytochemical-mediated favorable modulation of intestinal global metabolome
• Gut microbiome-dependent metabolism of phytochemicals to improve systemic bioavailability
• Beneficial effects of phytochemicals on intestinal cognate receptors.


Keywords: Gut barrier dysfunction, Gut-liver axis, Microbiome, Mucosal inflammation, Phytochemicals


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

26 July 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

26 July 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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