About this Research Topic
Early and sensitive detection of disease is of enormous scope in advancing early and preventative treatment that will make a major difference in diseases. Molecular imaging with biomarker targeted contrast agents is an emerging field that allows early detection of diseases. Targeted delivery of therapeutics to the disease sites would potentially increase the therapy efficiency and reduce side effects. The combination of therapeutic components with diagnostic/imaging agents (theranostics strategy) allows the tracking of the drugs and provides a transition from conventional medicine to a contemporary personalised and precision medicine approach.
Despite lots of attempts have been made in the field, current drug delivery systems still face poor efficiency of drug encapsulation, innate toxicity, unintended release of drugs, off-target effect or low accumulation of the drug at the disease site. A major proportion of nanomaterials or drugs is still cleared by the mononuclear phagocytic system or taken up by hepatocytes and Kupffers cells in the liver although targeted delivery is attempted. Similarly, molecular imaging and theranostics remain at their initial stage with lots of limitations.
The current Research Topic aims to cover promising, recent, and novel research trends in nanomaterials for diagnostics and therapy of life-threatening diseases such as cardiovascular disease, cancer, trauma bleeding, etc. Areas to be covered in this Research Topic may include, but are not limited to:
• Design and synthesis of new nanoprobes for diagnostic molecular imaging of life-threatening diseases.
• Design and synthesis of targeted therapeutic nanoplatforms.
• Novel theranostic nanomedicine approaches.
• Nanoprobes for image-guided surgery.
• Effects of nanomaterial’s physicochemical properties on the accumulation of the nanomedicine at the disease site and the biosafety of the nanomaterials.
Keywords: Theranostic Nanomedicine, Molecular Imaging, Cardiovascular diseases, Cancer, Trauma
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.