Research Topic

Intraoperative radiotherapy (IORT) – a New Frontier for Personalized Medicine as Adjuvant Treatment and Treatment of Locally Recurrent Advanced Malignancy: Volume II

About this Research Topic

The use of intraoperative radiation therapy has evolved in time from treatment that required significant shielding and set up costs to a more accessible tool to aid in treatment of cancer. In volume I of this series, we presented the radiobiology and physics of how intraoperative radiotherapy provides therapeutic advantage in providing a large dose to a target while minimizing toxicity to normal surrounding tissues. We also provided a framework for how Intraoperative radiotherapy (IORT) has been used in various malignancies from head and neck cancer, breast cancer, pelvic cancers and for palliation.

While the previous volume of this collection demonstrated great success, in volume II we aim to present updates to the technology application, recent advances, and results of recent studies reporting IORT outcomes. We will also highlight future directions and ongoing clinical trials in different tumor sites.

We welcome Original Research, Reviews, Clinical Trials, Methods and Opinion articles, covering but not limited to the below aspects:

• Biological Advantages of IORT
• Basic physics and planning of IORT
• Advances in IORT Applications for Breast Cancer
• Advances in IORT Applications for GI malignancies
• Advances in IORT Applications for Brain tumors
• Advances in IORT Applications for Pelvic malignancies
• Advances in IORT Applications for Head & Neck malignancies
• Advances in IORT Applications for Spine metastases


Keywords: intraoperative radiation, radiation therapy, radiotherapy, radiobiology, tumor toxicity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The use of intraoperative radiation therapy has evolved in time from treatment that required significant shielding and set up costs to a more accessible tool to aid in treatment of cancer. In volume I of this series, we presented the radiobiology and physics of how intraoperative radiotherapy provides therapeutic advantage in providing a large dose to a target while minimizing toxicity to normal surrounding tissues. We also provided a framework for how Intraoperative radiotherapy (IORT) has been used in various malignancies from head and neck cancer, breast cancer, pelvic cancers and for palliation.

While the previous volume of this collection demonstrated great success, in volume II we aim to present updates to the technology application, recent advances, and results of recent studies reporting IORT outcomes. We will also highlight future directions and ongoing clinical trials in different tumor sites.

We welcome Original Research, Reviews, Clinical Trials, Methods and Opinion articles, covering but not limited to the below aspects:

• Biological Advantages of IORT
• Basic physics and planning of IORT
• Advances in IORT Applications for Breast Cancer
• Advances in IORT Applications for GI malignancies
• Advances in IORT Applications for Brain tumors
• Advances in IORT Applications for Pelvic malignancies
• Advances in IORT Applications for Head & Neck malignancies
• Advances in IORT Applications for Spine metastases


Keywords: intraoperative radiation, radiation therapy, radiotherapy, radiobiology, tumor toxicity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

21 May 2021 Abstract
31 August 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

21 May 2021 Abstract
31 August 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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