About this Research Topic
Epigenetic controls are involved in maintaining size of organ to the organism shape, starting from the very beginning of ontogenesis to final tissue function. It represents one of the main mechanisms responsible for tissue regeneration. However, can we efficiently manipulate epigenetic machinery to achieve regeneration? Can regenerative medicine learn from development to achieve the desired functional organ regeneration?
The technological advancement in recent years allowed to study single cell behaviour, revealing the complex and heterogeneous scenario in biological systems in terms of cell identity and function (i.e. stem cells). Such complexity is also acting throughout development and in tissue regeneration. A deep understanding of epigenetics in development allowed reprogramming of fully differentiated cells into plastic progenitors (iPS cells generation), thus providing model systems for disease as well as new cell therapy options. Understanding the biology of mechanisms and phenomena behind developmental programs, which are also active in tissue regeneration, is indeed crucial. It would indeed help to design personalized medicine approaches on the basis of the epigenetic signature of the subject, therefore providing innovative visions to choose the best therapeutic route.
In this Research Topic, we aim to collect evidence regarding the role of epigenetic modulation and shed light on how diseases, tissues and systems progress over the time by acquiring new features through epigenetic modifications, ultimately enabling novel therapies and reducing potential side effects. Finally, epigenetics can also be modulated by the micro-environment of the cells, hence novel approaches for targeting epigenetics are anticipated in bioengineering to move knowledge from developmental processes into regenerative medicine.
We encourage submission of both Original Research and Review articles. We would appreciate methods and technology-oriented papers around current technological advances not limited to omics approaches but also including in vitro complex multicellular systems.
Topics of interest include:
• Epigenetic regulation of stem cell plasticity and differentiation
• Tissue plasticity: from ESC to neurons.
• Reprogramming and forced differentiation
• Extracellular vesicles in development and regeneration of tissues
• Non-coding RNA in development and regeneration
• Aging, senescence and rejuvenation
• Model systems (in vitro systems and in vivo epigenetic focused)
• Tissue sources with an interest on regenerative medicine approaches (comparative data between tissues)
• Regenerative cells potency improvement
• Epigenetic and disease development
• Targeting the epigenome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.