About this Research Topic
Sarcopenia is defined as a progressive and diffuse loss of skeletal muscle strength, mass, and function. Sarcopenia is acknowledged to be a multifactorial process that occurs due to changes in physical activity, hormone levels, nutrition, mitochondrial dysfunction, and chronic systemic inflammation. It is one of the leading causes of physical limitation in chronic liver diseases and is associated with a wide spectrum of adverse events including disability and mortality. Sarcopenia is an important prognostic factor, independent of MELD and Child-Pugh scores, in patients with cirrhosis awaiting liver transplantation. In patients who underwent liver transplantation, several studies showed an association between sarcopenia and post-transplantation survival. Malnutrition induces sarcopenia and both represent important causes/prerequisites leading to frailty.
Nutritional interventions combined with exercise bring some positive effects in the treatment of sarcopenia and frailty in patients with chronic liver diseases, but standardized protocols that can be universally implemented are still lacking.
This research topic welcomes papers analyzing the interplay between malnutrition, sarcopenia, and frailty in chronic liver diseases. The areas of interest are mentioned below:
PART 1
• Prevalence and risk factors for malnutrition, sarcopenia, and frailty in liver cirrhosis
• Outcomes and prognosis associated with sarcopenia/frailty before and after liver transplantation
• Nutritional screening and assessment in patients with chronic liver diseases
• Methods to assess sarcopenia and frailty in chronic liver diseases
• Impact of sarcopenia and frailty on quality of life in patients with chronic liver diseases
PART 2
• Chronic inflammation, sarcopenia, and sarcopenic obesity: Focus on NAFLD/NASH
• Nutritional interventions in NAFLD
• Nutrition and exercise in liver cirrhosis
• Managing malnutrition and sarcopenia in patients with alcoholic liver disease
• Nutritional status and eating behavior after liver transplantation
Nutritional interventions combined with exercise bring some positive effects in the treatment of sarcopenia and frailty in patients with chronic liver diseases, but standardized protocols that can be universally implemented are still lacking.
This research topic welcomes papers analyzing the interplay between malnutrition, sarcopenia, and frailty in chronic liver diseases. The areas of interest are mentioned below:
PART 1
• Prevalence and risk factors for malnutrition, sarcopenia, and frailty in liver cirrhosis
• Outcomes and prognosis associated with sarcopenia/frailty before and after liver transplantation
• Nutritional screening and assessment in patients with chronic liver diseases
• Methods to assess sarcopenia and frailty in chronic liver diseases
• Impact of sarcopenia and frailty on quality of life in patients with chronic liver diseases
PART 2
• Chronic inflammation, sarcopenia, and sarcopenic obesity: Focus on NAFLD/NASH
• Nutritional interventions in NAFLD
• Nutrition and exercise in liver cirrhosis
• Managing malnutrition and sarcopenia in patients with alcoholic liver disease
• Nutritional status and eating behavior after liver transplantation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
