Research Topic

Advances in Hepatic Tissue Engineering and Regeneration

About this Research Topic

Liver is a vital organ that performs more than five hundred biological functions. It is the only visceral organ that has capacity to regenerate in vivo. However, despite of its regenerative abilities in vivo, lack of long-term viable and functional hepatocytes in vitro, is one of the most important road blocks in several ex vivo applications as they are short lived in culture and also can dedifferentiate into other cell types. In vivo, liver/hepatocyte regeneration after a physiological insult is guided by several biophysical stimuli from the extracellular matrix (ECM) and biochemical signals from the neighboring cells. Both cells and the ECM act in a coordinated fashion to support liver regeneration in both physiology an pathology.

In recent years, several novel strategies and approaches have emerged to recapitulate liver microenvironment and thus facilitate regeneration and proliferation of liver cells ex vivo. Some of them include the development of 3D cultures of liver cells/stem cells as organoids, 3D bioprinting of liver cells, newer biomaterials and scaffolds (both natural and synthetic) resembling liver matrix for tissue engineering, dynamic perfusion cultures of cells etc. The use of decellularized native liver ECM represents one of the vital steps towards liver tissue engineering. In this Research Topic, we would emphasize on various novel cell and tissue engineering approaches that are being used to support long-term cultures of hepatic cells and fabrication of liver tissues for translational applications.

We welcome contributions (original articles, reviews, mini-reviews, perspectives) from topics encompassing liver tissue bioengineering, liver-on-chip, newer biomaterials, liver cell/organoid cultures, nano-engineering for liver, novel cell/molecular therapeutic approaches for liver regeneration etc. The goal of this Research Topic is to collate the expertise of tissue engineers and material scientists with cell/molecular biologists and liver physiologists that are working towards creating functional liver cells/tissues for wide-ranging clinical and preclinical applications.

Please note that abstract submission is not mandatory. Interested individuals and research groups are welcome to submit their manuscript to this Research Topic without submitting an abstract beforehand.


Keywords: Liver, Regeneration, Organoids, 3D Bioprinting, Tissue engineering, Liver Physiology


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Liver is a vital organ that performs more than five hundred biological functions. It is the only visceral organ that has capacity to regenerate in vivo. However, despite of its regenerative abilities in vivo, lack of long-term viable and functional hepatocytes in vitro, is one of the most important road blocks in several ex vivo applications as they are short lived in culture and also can dedifferentiate into other cell types. In vivo, liver/hepatocyte regeneration after a physiological insult is guided by several biophysical stimuli from the extracellular matrix (ECM) and biochemical signals from the neighboring cells. Both cells and the ECM act in a coordinated fashion to support liver regeneration in both physiology an pathology.

In recent years, several novel strategies and approaches have emerged to recapitulate liver microenvironment and thus facilitate regeneration and proliferation of liver cells ex vivo. Some of them include the development of 3D cultures of liver cells/stem cells as organoids, 3D bioprinting of liver cells, newer biomaterials and scaffolds (both natural and synthetic) resembling liver matrix for tissue engineering, dynamic perfusion cultures of cells etc. The use of decellularized native liver ECM represents one of the vital steps towards liver tissue engineering. In this Research Topic, we would emphasize on various novel cell and tissue engineering approaches that are being used to support long-term cultures of hepatic cells and fabrication of liver tissues for translational applications.

We welcome contributions (original articles, reviews, mini-reviews, perspectives) from topics encompassing liver tissue bioengineering, liver-on-chip, newer biomaterials, liver cell/organoid cultures, nano-engineering for liver, novel cell/molecular therapeutic approaches for liver regeneration etc. The goal of this Research Topic is to collate the expertise of tissue engineers and material scientists with cell/molecular biologists and liver physiologists that are working towards creating functional liver cells/tissues for wide-ranging clinical and preclinical applications.

Please note that abstract submission is not mandatory. Interested individuals and research groups are welcome to submit their manuscript to this Research Topic without submitting an abstract beforehand.


Keywords: Liver, Regeneration, Organoids, 3D Bioprinting, Tissue engineering, Liver Physiology


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 June 2021 Abstract
31 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 June 2021 Abstract
31 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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