Research Topic

Metabolism at war: How nutrient demand shapes immune responses and virulence during fungal infection

About this Research Topic

Metabolites are at the core of the battle between fungal pathogens and their hosts. During infection, animal fungal pathogens must adapt their metabolism to acquire and utilize required nutrients from surrounding tissue, and hence this effort drives the production of virulence attributes. Concomitantly, the host requires a well-balanced metabolism to support and to regulate effective immune responses. This interface is a battlefield in which the host must regulate its metabolic fluxes to mount an effective antimicrobial response and to try starving the pathogens from some nutrients and intoxicating them with others, whereas fungal pathogens need to acquire the nutrients from the tissues whilst trying to evade the host’s response and to subvert its metabolism.

This Research Topic will describe novel nutrition and metabolism-related features of fungal virulence, host defense and the host-pathogen interaction that drive fungal infection.

We particularly welcome manuscripts that address:
- Fungal metabolism during infection, including its regulation, macro- and micronutrient sensing, signaling and acquisition.
- Host metabolism and infection, immunometabolism, nutritional immunity and metabolic disorders.
- Metabolic crosstalk and regulation of host-pathogen interactions-in all stages of infection.
- Evolution of metabolic mechanisms during infection and consequences.


Keywords: Fungal Infections, Fungal Metabolism and Virulence, Host Metabolism and Immunity, Host-Fungal Interactions, Human and Animal Fungal Pathogens


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Metabolites are at the core of the battle between fungal pathogens and their hosts. During infection, animal fungal pathogens must adapt their metabolism to acquire and utilize required nutrients from surrounding tissue, and hence this effort drives the production of virulence attributes. Concomitantly, the host requires a well-balanced metabolism to support and to regulate effective immune responses. This interface is a battlefield in which the host must regulate its metabolic fluxes to mount an effective antimicrobial response and to try starving the pathogens from some nutrients and intoxicating them with others, whereas fungal pathogens need to acquire the nutrients from the tissues whilst trying to evade the host’s response and to subvert its metabolism.

This Research Topic will describe novel nutrition and metabolism-related features of fungal virulence, host defense and the host-pathogen interaction that drive fungal infection.

We particularly welcome manuscripts that address:
- Fungal metabolism during infection, including its regulation, macro- and micronutrient sensing, signaling and acquisition.
- Host metabolism and infection, immunometabolism, nutritional immunity and metabolic disorders.
- Metabolic crosstalk and regulation of host-pathogen interactions-in all stages of infection.
- Evolution of metabolic mechanisms during infection and consequences.


Keywords: Fungal Infections, Fungal Metabolism and Virulence, Host Metabolism and Immunity, Host-Fungal Interactions, Human and Animal Fungal Pathogens


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

15 September 2021 Abstract
15 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

15 September 2021 Abstract
15 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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