Research Topic

Flexible Electrochemical Biosensors: Materials and Devices

About this Research Topic

Organic bioelectronics is an emerging technology area that couples the revolutionary field of organic electronics with the vast and eclectic field of biology. The emergence of this new and exciting technology area has enabled us to address the present and future diagnostic and therapeutic needs of the biomedical community. These needs include detecting low concentrations of biological analytes as well as improving compatibility with the biological environment. Among various currently used approaches, electrochemical detection techniques stand out due to their simplicity, specificity, and excellent performance, and also due to the fact that they are usually not expensive or time consuming. In fact, electrochemical biosensor systems are have emerged as preferred elements in the field of bioelectronics due to their exceptional ability to interface electronics with biology. Their compatibility with a wide range of biorecognition elements allows effective conversion of biochemical signals into electronic ones and, in most cases, their impressive transduction ability ensures high signal-to noise of the output signal. Hence, electrochemical biosensing using devices like organic electrochemical transistors (OECTs), chemiresistors, bio-organic field-effect transistor (Bio-OFETs), bio-microelectromechanical systems (BioMEMS), bioluminescent sensors, etc. hold the ability to provide high sensitivity and low limit of detection.

Keeping in view the much needed progress in the field of portable, low-cost and low power consumption biosensors, this Research Topic invites contributions involving the development of electrochemical biosensor devices prepared on flexible, stretchable or deformable substrates that show sensitivity to specific bioanalytes, including (but not limited to) ions, lactate, glucose, hormones, DNA, bacteria, protein, and cells. The topic will provide a platform to address and improve the core aspects of various flexible biosensors to make them potentially useful in some emerging areas, such as wearable electronics, electronic skin, and body-integrated implantable sensors. There are numerous ongoing research efforts in biosensor technology as these devices need to operate at low voltages (< 1 V), exhibit high biocompatibility and good compatibility with unconventional substrates. We invite authors to contribute articles that will stimulate the continuing efforts to optimize the performance of flexible electrochemical biosensors using both materials design and device engineering techniques, while keeping an eye on the challenges that the electrochemical biosensor technology will face in the near future.

Topics of interest include, but are not limited to:
- Design and development of flexible biosensor devices.
- Optimization of the electrical, mechanical and biosensing performance of biosensors through improvement of device physics and device engineering aspects
- Development of innovative strategies for the fabrication of various sensor layers, and their compatibility with unconventional substrates, including flexible, stretchable and deformable
- Design and development of new materials with engineered properties and understanding the interplay of their properties with the performance of biosensor devices
- Development and optimization of design guidelines of future materials
- Development of cutting-edge techniques for functionalization of the active sensing surfaces, and understanding of the fundamental mechanisms related to the immobilization and sensing of biomarkers
- Design and fabrication of wearable biosensors to monitor biomarkers in body fluids
- Device performance, stability, reliability, scalability and commercial applicability


Keywords: Flexible biosensors, bioelectronics, OECTs, electrochemical sensing, organic transistors, materials, BioMEMS, BioFETs, chemiresistors


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Organic bioelectronics is an emerging technology area that couples the revolutionary field of organic electronics with the vast and eclectic field of biology. The emergence of this new and exciting technology area has enabled us to address the present and future diagnostic and therapeutic needs of the biomedical community. These needs include detecting low concentrations of biological analytes as well as improving compatibility with the biological environment. Among various currently used approaches, electrochemical detection techniques stand out due to their simplicity, specificity, and excellent performance, and also due to the fact that they are usually not expensive or time consuming. In fact, electrochemical biosensor systems are have emerged as preferred elements in the field of bioelectronics due to their exceptional ability to interface electronics with biology. Their compatibility with a wide range of biorecognition elements allows effective conversion of biochemical signals into electronic ones and, in most cases, their impressive transduction ability ensures high signal-to noise of the output signal. Hence, electrochemical biosensing using devices like organic electrochemical transistors (OECTs), chemiresistors, bio-organic field-effect transistor (Bio-OFETs), bio-microelectromechanical systems (BioMEMS), bioluminescent sensors, etc. hold the ability to provide high sensitivity and low limit of detection.

Keeping in view the much needed progress in the field of portable, low-cost and low power consumption biosensors, this Research Topic invites contributions involving the development of electrochemical biosensor devices prepared on flexible, stretchable or deformable substrates that show sensitivity to specific bioanalytes, including (but not limited to) ions, lactate, glucose, hormones, DNA, bacteria, protein, and cells. The topic will provide a platform to address and improve the core aspects of various flexible biosensors to make them potentially useful in some emerging areas, such as wearable electronics, electronic skin, and body-integrated implantable sensors. There are numerous ongoing research efforts in biosensor technology as these devices need to operate at low voltages (< 1 V), exhibit high biocompatibility and good compatibility with unconventional substrates. We invite authors to contribute articles that will stimulate the continuing efforts to optimize the performance of flexible electrochemical biosensors using both materials design and device engineering techniques, while keeping an eye on the challenges that the electrochemical biosensor technology will face in the near future.

Topics of interest include, but are not limited to:
- Design and development of flexible biosensor devices.
- Optimization of the electrical, mechanical and biosensing performance of biosensors through improvement of device physics and device engineering aspects
- Development of innovative strategies for the fabrication of various sensor layers, and their compatibility with unconventional substrates, including flexible, stretchable and deformable
- Design and development of new materials with engineered properties and understanding the interplay of their properties with the performance of biosensor devices
- Development and optimization of design guidelines of future materials
- Development of cutting-edge techniques for functionalization of the active sensing surfaces, and understanding of the fundamental mechanisms related to the immobilization and sensing of biomarkers
- Design and fabrication of wearable biosensors to monitor biomarkers in body fluids
- Device performance, stability, reliability, scalability and commercial applicability


Keywords: Flexible biosensors, bioelectronics, OECTs, electrochemical sensing, organic transistors, materials, BioMEMS, BioFETs, chemiresistors


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

17 May 2021 Abstract
15 August 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

17 May 2021 Abstract
15 August 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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