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In addition to tumor-related proteins and their coding genes, non-coding genes are also closely related to the occurrence and development of tumors. In particular, miRNAs, a class of highly conserved non-coding single-chain molecules, can inhibit gene expression at the post-transcriptional level by ...

In addition to tumor-related proteins and their coding genes, non-coding genes are also closely related to the occurrence and development of tumors. In particular, miRNAs, a class of highly conserved non-coding single-chain molecules, can inhibit gene expression at the post-transcriptional level by incomplete-complementary pairing with the untranslated regions of multiple genes.

miRNAs are localized in tumor-related genomic regions and chromosome abnormalities can directly lead to changes in the copy number of miRNAs, thus resulting in an imbalance of expression in a variety of tumor related genes. Therefore, miRNAs can promote or repress the expression of oncogenes or tumor-suppressor genes. These abnormal expressions detected in almost all tumor tissues can reflect their tissue origin and can be used for molecular typing of tumors. Previous studies demonstrate that miRNAs participate in almost every step in the occurrence and development of tumors and plays an important role in tumor pathogenesis.

Consequently, this topic aims to exploit novel miRNAs that could regulate the expression of tumor related genes, thus controlling the occurrence and progress of tumor. Meanwhile, the cellular, molecular and pathogenic mechanism of tumorigenesis regulation by miRNA is also to be elucidated in this topic.

We welcome the following submissions covering:
• miRNAs that could promote tumorigenesis their mechanisms
• miRNAs that could repress tumorigenesis and their mechanisms
• The exploitation of mRNAs that could regulate tumorigenesis by bioinformatics and the demonstration of thereof function
• Applications of miRNAs to control the occurrence and progress of tumors, and how they may affect human health

Dr. Guangchao Li receives funding from Guangzhou Baiji Gene Technology Co., LTD, all other Topic Editors declare no conflicts of interest

Keywords: miRNA, genekonockout, regulation, tumorgenesis, stemness of cancer cell, overexpression


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