About this Research Topic
Despite the slight reduction in cases seen in parts of Africa over the last few years, malaria remains a major global health challenge. A combination of the emergence of parasite resistance to most of the available antimalarial drugs and mosquito resistance to insecticides poses a serious threat to malaria control. While a vaccine would be a cost-effective addition to the malaria control armamentarium, the most effective vaccine today is only about 50% effective. There is, therefore, a strong impetus to continue hunting for more effective malaria vaccines. A major hurdle to malaria vaccine development has been the inability to define clear correlates of protective immunity. Malaria infection provokes a wide range of immune responses due to the biological complexity of the malaria parasite and its life cycle. Distinguishing between protective and non-protective responses within this complex immunological milieu remains the main challenge for malaria immunology researchers. This collection is aimed at expanding our understanding of immunity to malaria by collating the latest research in this field.
Keywords: malaria immunology, malaria vaccine, malaria, vaccine development, immunology
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