About this Research Topic
This Research Topic is part of The Role of Glia in Plasticity and Behavior series:
The Role of Glia in Plasticity and Behavior
Glial cells are now found to actively participate in regulating the physiological and pathological functions, development, plasticity of brain circuits, and the control of behavior. Astrocytes are implicated in the regulation of many processes including, but not limited to, synaptic plasticity, memory processing, brain rhythms, sleep homeostasis, cognition, and depression. New technologies such as optogenetics, chemogenetics, viral expression of transgenes, transcriptional profiling, metabolomics, genetically encoded biosensors help to elucidate the molecular mechanisms underlying these processes and to understand the heterogeneous nature of glial cells in the central nervous system (CNS). Taken together, current evidence is strongly suggestive that glial cells are essential contributors to neural circuit regulation, leading to short- and long-range plasticity and eventually to behavioral changes under both physiological and pathological conditions.
In the second volume of this Research Topic, we aim to summarize our most recent understanding of glial cells with respect to the regulation of plasticity of neural circuits, entrainment of brain rhythms, and the control of behavior, cognition, and plasticity. Likewise, we are interested in understanding how glial cells are activated in response to behavior and under disease conditions. We welcome submissions that try to find common motifs in glial function across brain regions or species. Furthermore, we welcome submissions presenting novel tools that can be used to control and read-out the function and metabolism of glial cells in the intact brain.
Suggested topics include, but are not limited to:
- Glial control of extracellular ionic gradients, excitability, and metabolism
- Glial signaling during, in response to, or triggering behavior
- Role of glia in short and long-term plasticity, and cognition
- Glial activation and plasticity under pathological conditions (injury and neurodegenerative diseases)
- Cross-species comparisons of glial function
- Computational aspects of glial signaling in vivo
- Entrainment of brain rhythms by glial cells
- Novel tools to probe glial signaling and function in vivo
Keywords: Glial Cells, Neural Circuits, Memory, Behavior, Synaptic Plasticity
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