Research Topic

Deciphering Blood to Defeat Brain Disorders

About this Research Topic

There has been a historic leap forward in the deciphering of blood composition. It is now possible to study blood composition thanks to omic approaches (genomic, proteomic, metabolomics, and lipidomic) and, thanks to artificial intelligence, to understand the complex blood signals involved during cerebral disorders (Aging, Brain tumor, Parkinson’s, and Other Movement Disorders, Alzheimer's disease, Epilepsy, and Other Seizure Disorders, Mental Disorders, Stroke, and Transient Ischemic Attack, cerebral consequences due to Cardiac, Liver or Kidney insufficiency). These signals can be deregulations of blood concentration of proteins, metabolites, or lipids. These molecules could either be of cerebral origin or of peripheral origin (liver, kidneys, microbiota) and could be a cause or consequence of a brain disorder.
These deregulations are often complex and dynamic and require analysis using the last artificial intelligence approaches to be deciphered. This unprecedented understanding will undoubtedly make it possible to develop tomorrow's clinical management thanks to both diagnosis and blood-based therapies.

These advances are at the crossroads of many sciences such as oncology, neuroscience, metabolic diseases, but also artificial intelligence and omics dosing techniques. It is, therefore, crucial to decompartmentalize specialties in order to have a global and certainly more accurate vision of the potential offered by the deciphering of the blood constitution. However, these work too often remain focused on one expertise. We would therefore like to offer a space for reflection and sharing that is totally open to all types of expertise to provide an overview of the immense challenge of deciphering blood to defeat brain disorders.


•             New assays to dose blood constituents (mass spectrometry assays, antibody-based tests, flow cytometry assays, …),

•             New Artificial Intelligence approaches to decipher the blood complexity,

•             New blood biomarkers or combinaisons of biomarkers for cerebral diseases diagnosis or prognosis.

•             New therapeutic strategies based on blood constitution control



Dr. Braudeau is the co-founder and CEO of AgenT, Dr. Lehallier is the Director of
Data Science at Alkahest Inc. The other Topic Editors declare no competing interests.



Keywords: Computational biology, Blood, omics, Neurodegenerative disorders, Cancer


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

There has been a historic leap forward in the deciphering of blood composition. It is now possible to study blood composition thanks to omic approaches (genomic, proteomic, metabolomics, and lipidomic) and, thanks to artificial intelligence, to understand the complex blood signals involved during cerebral disorders (Aging, Brain tumor, Parkinson’s, and Other Movement Disorders, Alzheimer's disease, Epilepsy, and Other Seizure Disorders, Mental Disorders, Stroke, and Transient Ischemic Attack, cerebral consequences due to Cardiac, Liver or Kidney insufficiency). These signals can be deregulations of blood concentration of proteins, metabolites, or lipids. These molecules could either be of cerebral origin or of peripheral origin (liver, kidneys, microbiota) and could be a cause or consequence of a brain disorder.
These deregulations are often complex and dynamic and require analysis using the last artificial intelligence approaches to be deciphered. This unprecedented understanding will undoubtedly make it possible to develop tomorrow's clinical management thanks to both diagnosis and blood-based therapies.

These advances are at the crossroads of many sciences such as oncology, neuroscience, metabolic diseases, but also artificial intelligence and omics dosing techniques. It is, therefore, crucial to decompartmentalize specialties in order to have a global and certainly more accurate vision of the potential offered by the deciphering of the blood constitution. However, these work too often remain focused on one expertise. We would therefore like to offer a space for reflection and sharing that is totally open to all types of expertise to provide an overview of the immense challenge of deciphering blood to defeat brain disorders.


•             New assays to dose blood constituents (mass spectrometry assays, antibody-based tests, flow cytometry assays, …),

•             New Artificial Intelligence approaches to decipher the blood complexity,

•             New blood biomarkers or combinaisons of biomarkers for cerebral diseases diagnosis or prognosis.

•             New therapeutic strategies based on blood constitution control



Dr. Braudeau is the co-founder and CEO of AgenT, Dr. Lehallier is the Director of
Data Science at Alkahest Inc. The other Topic Editors declare no competing interests.



Keywords: Computational biology, Blood, omics, Neurodegenerative disorders, Cancer


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

24 May 2021 Abstract
23 November 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

24 May 2021 Abstract
23 November 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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