Research Topic

Preclinical Animal Models of Chronic Pain in Autoimmune Diseases

About this Research Topic

Chronic pain is one of the most debilitating health problems resulting in reduced quality of life. There are currently few effective medications for chronic pain and thus, it remains a therapeutic challenge. It is important to advance our knowledge on chronic pain mechanisms and therefore preclinical research focusing on exploring novel pain pathways is crucial. It has been shown before that the communication between neurons and immune cells contributes to the development of chronic pain, even without ongoing inflammation. The presence and involvement of autoantibodies in several painful conditions, such as rheumatoid arthritis, Morvan’s disease, complex regional pain syndrome, have already been studied.

Despite great efforts, the detailed pathology of most autoimmune diseases and the related pain conditions are complex and not fully understood. Therefore, there is a great need for preclinical animal models mimicking the human condition to understand the underlying mechanisms. While currently there are well-established animal models of chronic pain in certain autoimmune diseases, there are other diseases for which the right models still have to be developed, or the translational value of the models needs to be proven. As none of these models can fulfill the pathology and all symptoms of a complex disease, several models can be equally important and relevant from different perspectives. These models together can contribute to a better understanding of chronic pain.

Overall, any paper aiming to describe or characterize an autoimmune disease from a chronic pain perspective is welcome in this research topic.
Special focus will be given (but is not restricted) to:
• Characterization of an animal model of chronic pain in autoimmune disease
• Chronic pain management in an autoimmune animal model
• Chronic pain mechanisms in an autoimmune animal model
• The use of non-evoked measures in characterizing chronic pain in an autoimmune animal model
• An overview of the current challenges of animal models of autoimmune diseases


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Chronic pain is one of the most debilitating health problems resulting in reduced quality of life. There are currently few effective medications for chronic pain and thus, it remains a therapeutic challenge. It is important to advance our knowledge on chronic pain mechanisms and therefore preclinical research focusing on exploring novel pain pathways is crucial. It has been shown before that the communication between neurons and immune cells contributes to the development of chronic pain, even without ongoing inflammation. The presence and involvement of autoantibodies in several painful conditions, such as rheumatoid arthritis, Morvan’s disease, complex regional pain syndrome, have already been studied.

Despite great efforts, the detailed pathology of most autoimmune diseases and the related pain conditions are complex and not fully understood. Therefore, there is a great need for preclinical animal models mimicking the human condition to understand the underlying mechanisms. While currently there are well-established animal models of chronic pain in certain autoimmune diseases, there are other diseases for which the right models still have to be developed, or the translational value of the models needs to be proven. As none of these models can fulfill the pathology and all symptoms of a complex disease, several models can be equally important and relevant from different perspectives. These models together can contribute to a better understanding of chronic pain.

Overall, any paper aiming to describe or characterize an autoimmune disease from a chronic pain perspective is welcome in this research topic.
Special focus will be given (but is not restricted) to:
• Characterization of an animal model of chronic pain in autoimmune disease
• Chronic pain management in an autoimmune animal model
• Chronic pain mechanisms in an autoimmune animal model
• The use of non-evoked measures in characterizing chronic pain in an autoimmune animal model
• An overview of the current challenges of animal models of autoimmune diseases


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

25 August 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

25 August 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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