About this Research Topic
Inflammation represents the physiological response to possible harmful agents, such as germs, toxins, environmental pollutants, injuries of various nature or other stressors. Damaged or diseased tissues attract pro-inflammatory and immune cells in the interested area through several autacoid mediators, such as cytokines and chemokines. The ultimate result is the elimination of the infectious agent or damaged tissue and the initiation of the healing process. Inflammation can be controlled and modulated through novel pharmacological strategies and is as well subjected to the effect of the environment. The perfect balance of the immune system represents an important point to avoid the development of chronic diseases and the increasing susceptibility to bacterial infections.
Inflammation and immune system disbalance that is not recognized, or does not show obvious clinical signs, can cause subclinical conditions that can compromise the patient's health. The resulting clinical deterioration can progress to sepsis, multiple organ failure or into other chronic diseases. The aim of this thread is to gather the cutting-edge scientific contributions about immunomodulation in veterinary science and animal production. Research articles uncovering immunomodulation strategies, mechanisms and applications will be particularly welcome, with the final goal of improving drug treatment and of developing safer strategies possibly focused on natural bioproducts.
The round table discussion will be centered on inflammation mechanisms and their modulation in relation to the One Health perspective. The editors will be very happy to take onboard contributions improving the knowledge about pharmacokinetics and pharmacodynamics of already known and novel drugs active on immune system. Moreover, new studies and discoveries considering natural compounds and bioproducts involved in inflammation modulation are particularly encouraged.
Areas to be covered in this Research Topic may include, but are not limited to:
• Preclinical and clinical studies of inflammatory and neuroinflammatory diseases
• Natural treatments to improve animal health, animal welfare and immune status
• Nutraceuticals and antioxidants as anti-inflammatory/immunomodulating drugs
Keywords: immunomodulation, treatment, inflammation, therapeutic, non-resolving
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.