About this Research Topic
The DNA is a nanosized molecule and as such, it requires nanotechnology to study its properties in great detail. Research on various aspects of the DNA replication process, including mechanical ones, is therefore highly relevant. Recent work from scientists at Cornell University examines the chromatin mechanical and topological properties, which allow DNA strand separation without entanglement. However, features of the electromagnetic forces acting in the DNA replication process remain outside the scope of this discussion. The helicase effect on the DNA molecule during DNA replication is mild and non-destructive. However, other influences of various external factors are also possible, leading to a change in the DNA state and even its damage. Over the past few years, research has intensified on various states of the DNA molecule: supercoiled, relaxed and linear. Various possible mechanisms of the DNA molecule transitions between different states, including those under the action of electrons or intense IR radiation, are considered. The physical properties of the DNA molecule are the basis for its use in nanotechnology. The potential real-world applications of DNA nanotechnology, the potential of synthetic DNA nanostructures for personalized drugs and therapeutics are a matter of interest within the nanomaterials science studies. The ability of nucleic acid arrays to arrange other molecules indicates its potential applications in molecular scale electronics.
This Research Topic will focus on the investigation of the physical properties of the DNA molecule as the basis of nanodevices and nanotechnologies. It will also consider a wide range of applications of the DNA molecule and DNA-like helices in nanotechnology applications. The creation of a physically-based model of the DNA replication process, alongside with a computer model that considers electromagnetic forces will be of particular interest for this collection. Additionally, in the context modelling context, the determination of electromagnetic parameters and conditions that provide the helicase non-damaging effect in the replication process will be considered. The model will represent the basis of a standard for natural, undamaged DNA duplication, including possible violations of the natural process of DNA replication at any stage. The collection of articles will identify some damaging factors potentially dangerous to the DNA, leading to an unnatural, pathological change in the DNA. Possible determination of causes and conditions for the early-onset cancer at the DNA level are also of interest.
We welcome Original Research Articles, Reviews, Mini Reviews on the following topics (but not limited to):
• Experimental studies of the DNA electrical conductivity at various sections and the construction of the equivalent electrical circuit for the double helix of the DNA molecule
• Experimental studies of the DNA molecule absorption in different wavelength ranges
• Consideration of possible mechanisms of the DNA molecule transitions between its different states (supercoiled, relaxed and linear), considering the action of electrons or intense IR radiation
• Design and manufacture of artificial nucleic acid structures for technological uses (DNA nanotechnology).
• The nanoscale folding of DNA to create arbitrary two- and three-dimensional shapes at the nanoscale (DNA origami)
• Synthesizing and characterizing nucleic acid complexes and materials where the assembly has a static, equilibrium endpoint (Structural DNA nanotechnology)
• Forming nucleic acid systems with designed dynamic functionalities related to their overall structures, such as computation and mechanical motion (Dynamic DNA nanotechnology)
• Conducting nanostructures based on metallized DNA as future electronic components
Keywords: DNA Replication, DNA Damage, Electromagnetics, Mechanisms, DNA Molecule Transition, Nanotechnology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.