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Gene function, including that of coding and non-coding genes, can be difficult to identify in molecular wet laboratories. Therefore, computational methods, often including machine learning, may be a useful tool to guide and predict function. Although machine learning has been considered a “black box” in the ...

Gene function, including that of coding and non-coding genes, can be difficult to identify in molecular wet laboratories. Therefore, computational methods, often including machine learning, may be a useful tool to guide and predict function. Although machine learning has been considered a “black box” in the past, it can be more accurate than simple statistical testing methods. In recent years, deep learning and big data machine learning techniques have developed rapidly and achieved an amazing level of performance in many areas including image classification and speech recognition.

In our first instalment, Machine Learning Techniques on Gene Function Prediction Volume I, we found most authors paid attention to gene and ncRNA function prediction. This Research topic will further explore the potential for machine learning applied to gene function prediction. Moreover, we would also like to share some works on single-cell sequencing data analysis and related machine learning methods.

We hope that code describing novel methodology and data from real-world applications can be presented together in this issue. The list of possible topics includes, but not limited to:
- Latest machine learning algorithms on gene function prediction;
- Reviews or surveys with benchmark datasets in gene function prediction;
- Deep learning techniques with applications in gene function prediction;
- Non-coding gene functional computational analysis;
- Machine learning methods on single cell sequencing data.

Keywords: Machine learning, Genetics, Bioinformatics, Feature selection, Deep learning, Single cell sequencing data


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