Skip to main content

About this Research Topic

Submission closed.

Genetically encoded indicators emerged as promising tools for cell type-specific and chronic recording of neuronal population activity. Since publication of the first prototypical genetically encoded Ca2+ indicators (Cameleons) in 1997, we have witnessed remarkable evolution of the field, with rapid ...

Genetically encoded indicators emerged as promising tools for cell type-specific and chronic recording of neuronal population activity. Since publication of the first prototypical genetically encoded Ca2+ indicators (Cameleons) in 1997, we have witnessed remarkable evolution of the field, with rapid improvement of indicator performance as well as expanded application to many model organisms in the neuroscience community. Challenges still remain, however, concerning the mammalian central nervous system: limited sensitivity of indicators to small number of activity, slow signal kinetics, cytotoxicity after a long-term and high-level expression of indicators, and variable performance across cell types.

In this Research Topic, we encourage top researchers in the field and their young colleagues to present their cutting-edge research as well as insightful opinions on the following subtopics:
1) Latest breakthroughs on development of genetically encoded indicators
2) Novel scientific findings obtained with genetically encoded indicators
3) Wishlist for the next-generation genetically encoded indicators
4) Guideline for selecting an appropriate indicator
5) Optimal methodology for indicator delivery to mammalian CNS

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic Editors

Loading..

Topic Coordinators

Loading..

Recent Articles

Loading..

Articles

Sort by:

Loading..

Authors

Loading..

views

total views views downloads topic views

}
 
Top countries
Top referring sites
Loading..

Share on

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.