Research Topic

Gut Microbiome and Metabolites Regulate Blood-Brain Barrier during Neuroinflammation and Neurodegenerative Diseases

About this Research Topic

Our gut microbiota and its metabolites regulate many physiological processes in the body. Recently, more and more studies have shown that disorders of gut microbiota are closely related to many nervous system diseases, including depression, Alzheimer’s disease, multiple sclerosis and cognitive dysfunction. For instance, research has shown that under sterile conditions, Alzheimer's disease model mice showed fewer cerebral β-amyloid plaques. Through antibiotic administration, we can also improve β-amyloid pathology and neuroinflammation in the same model. It is worth mentioning that the absence of gut microbes decreases expression of tight junction proteins, leading to increased permeability of blood-brain barrier (BBB), which may directly or indirectly influence neuroinflammation and neurodegenerative diseases. All these indicate that gut microbiota may play a regulatory role in neuroinflammation and neurodegenerative diseases in some way.

The goal of this Research Topic is to provide a forum to advance research on the contribution of gut microbiome and metabolites in regulating the blood-brain barrier during neuroinflammation and neurodegenerative diseases as well as to explore innovative gut-oriented pharmacological interventions in the attempt to achieve a beneficial impact on neuroinflammation and neurodegenerative diseases. We welcome submissions of Original Article, Review, Mini Review, and Methods on the sub-topics below:

• Mechanisms of gut microbial metabolites regulating the BBB.
• Changes in the BBB in neuroinflammatory and neurodegenerative diseases.
• Changes in the gut microbiome and metabolites during neuroinflammatory and neurodegenerative diseases.
• Strategies for the prevention and/or treatment of neuroinflammatory and neurodegenerative diseases targeting intestinal microbes.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Our gut microbiota and its metabolites regulate many physiological processes in the body. Recently, more and more studies have shown that disorders of gut microbiota are closely related to many nervous system diseases, including depression, Alzheimer’s disease, multiple sclerosis and cognitive dysfunction. For instance, research has shown that under sterile conditions, Alzheimer's disease model mice showed fewer cerebral β-amyloid plaques. Through antibiotic administration, we can also improve β-amyloid pathology and neuroinflammation in the same model. It is worth mentioning that the absence of gut microbes decreases expression of tight junction proteins, leading to increased permeability of blood-brain barrier (BBB), which may directly or indirectly influence neuroinflammation and neurodegenerative diseases. All these indicate that gut microbiota may play a regulatory role in neuroinflammation and neurodegenerative diseases in some way.

The goal of this Research Topic is to provide a forum to advance research on the contribution of gut microbiome and metabolites in regulating the blood-brain barrier during neuroinflammation and neurodegenerative diseases as well as to explore innovative gut-oriented pharmacological interventions in the attempt to achieve a beneficial impact on neuroinflammation and neurodegenerative diseases. We welcome submissions of Original Article, Review, Mini Review, and Methods on the sub-topics below:

• Mechanisms of gut microbial metabolites regulating the BBB.
• Changes in the BBB in neuroinflammatory and neurodegenerative diseases.
• Changes in the gut microbiome and metabolites during neuroinflammatory and neurodegenerative diseases.
• Strategies for the prevention and/or treatment of neuroinflammatory and neurodegenerative diseases targeting intestinal microbes.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

16 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

16 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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