Research Topic

Toxicity Impact of Nanomaterials in Food Production

About this Research Topic

There is a need to produce food in a more efficient, safe, and sustainable way. Nanotechnology offers the opportunity to provide innovative approaches to increase food shelf-life and freshness, to enhance its organoleptic and nutraceutical properties, and to reduce production waste. Despite these advantages, the knowledge about the human risk assessment of the oral uptake of engineered nanomaterials (ENMs) in food is still poor, although ENMs are widely used in food additives and supplements. Several studies focus on the fate and effects of food-borne nanoparticles (NPs), with the aim to make consistent regulatory guidelines, standardizing the in vitro and in vivo analytical techniques. In particular, the different physico-chemical properties such as size, charge, aggregation state, morphology and composition of ENMs are demonstrated to drive adverse effects in biological systems. In this context, it is imperative to understand their influence on the gastro-intestinal tract and the probability to generate toxicity.

Despite the recent increase in research about the potential toxic effects of ENMs used in food production, the results remain contradictory. This stems from the diverse techniques used for material characterization, and from the different types of ENMs which are considered for comparison’s sake. Moreover, many research works study the pristine nanomaterials and ignore the interactions between ENMs and environment/biological fluids that can promote the ENMs aggregation and dispersion, both influencing cell uptake with a consequent impact on the ENMs toxicity. For this reason, more realistic experimental conditions and a more rigorous comparison of the physico-chemical properties of nanomaterials would be extremely crucial to understand their toxicological behavior.

This Research topic is devoted to creating a rationale about the toxicological behavior of nanomaterials used in food production with a particular focus on the gastrointestinal toxicity at different levels (stomach, intestine, intestinal microbiota, and intestinal immune cells). The toxicity of different kinds of amorphous silica, anatase and rutile titania, and silver nanoparticles will be addressed. Moreover, an in-depth study of the ADME pathway (absorption, distribution, metabolism and elimination or excretion) of oral pharmaceutical preparations based on biopolymers (chitosan, starch, β-Lactoglobulin, zein, extracellular polymeric materials) as sustainable and cost-effective nano-delivery systems will be performed.

Type of manuscripts welcome in the collection: Original Research articles and Reviews.


Keywords: Gastrointestinal Toxicity, Metal Oxide Nanoparticles, Metal Nanoparticles, Food Additives, Biocompatible Compounds, Nutraceutical


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

There is a need to produce food in a more efficient, safe, and sustainable way. Nanotechnology offers the opportunity to provide innovative approaches to increase food shelf-life and freshness, to enhance its organoleptic and nutraceutical properties, and to reduce production waste. Despite these advantages, the knowledge about the human risk assessment of the oral uptake of engineered nanomaterials (ENMs) in food is still poor, although ENMs are widely used in food additives and supplements. Several studies focus on the fate and effects of food-borne nanoparticles (NPs), with the aim to make consistent regulatory guidelines, standardizing the in vitro and in vivo analytical techniques. In particular, the different physico-chemical properties such as size, charge, aggregation state, morphology and composition of ENMs are demonstrated to drive adverse effects in biological systems. In this context, it is imperative to understand their influence on the gastro-intestinal tract and the probability to generate toxicity.

Despite the recent increase in research about the potential toxic effects of ENMs used in food production, the results remain contradictory. This stems from the diverse techniques used for material characterization, and from the different types of ENMs which are considered for comparison’s sake. Moreover, many research works study the pristine nanomaterials and ignore the interactions between ENMs and environment/biological fluids that can promote the ENMs aggregation and dispersion, both influencing cell uptake with a consequent impact on the ENMs toxicity. For this reason, more realistic experimental conditions and a more rigorous comparison of the physico-chemical properties of nanomaterials would be extremely crucial to understand their toxicological behavior.

This Research topic is devoted to creating a rationale about the toxicological behavior of nanomaterials used in food production with a particular focus on the gastrointestinal toxicity at different levels (stomach, intestine, intestinal microbiota, and intestinal immune cells). The toxicity of different kinds of amorphous silica, anatase and rutile titania, and silver nanoparticles will be addressed. Moreover, an in-depth study of the ADME pathway (absorption, distribution, metabolism and elimination or excretion) of oral pharmaceutical preparations based on biopolymers (chitosan, starch, β-Lactoglobulin, zein, extracellular polymeric materials) as sustainable and cost-effective nano-delivery systems will be performed.

Type of manuscripts welcome in the collection: Original Research articles and Reviews.


Keywords: Gastrointestinal Toxicity, Metal Oxide Nanoparticles, Metal Nanoparticles, Food Additives, Biocompatible Compounds, Nutraceutical


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

30 June 2021 Abstract
31 October 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

30 June 2021 Abstract
31 October 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..