About this Research Topic
The encapsulation of bioactive compounds in biocompatible delivery systems has been shown to be an efficacious approach for modulating the pharmacological and biopharmaceutical properties of the bioactives. Among the various biomaterials used, natural polymers have been exploited for the development of micelles, micro/nanoparticles, conjugates and (hydro)gels able to retain, protect and release various drugs in a controlled manner. These formulations efficiently interact with the biological barriers to increase the cell uptake and tissue localization of the entrapped bioactive compounds. They also decrease the side effects of different drugs. Moreover, natural-based nanosystems promote the systemic administration of lipophilic drugs in aqueous media, preventing the necessity of using toxic organic solvents. This improves their therapeutic efficacy. Not less important is to address the interaction of natural polymers with the immune system. Nanomedicines need to avoid immune recognition in order to reach their therapeutic target and carry out their effect, and should not trigger or interfere with the defense mechanisms of the body. The aim of this Special Issue is to describe the advancements concerning the development and the immuno-safety of innovative biocompatible formulations made up of natural polymers used as drug carriers for pharmaceutical and biomedical applications. All researchers working in the field are cordially invited to contribute. Original research papers, brief communication reports and review articles are all welcome.
Keywords: Colloidal structures, Drug delivery, Microparticulates, Natural polymers, (poly)saccharides, Proteins
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