Advances in Treatment of Recurrent and Metastatic Nasal-Cranial Base Tumors

Nasal-skull base tumors can be broadly classified into nasal cavity tumors, skull base tumors, and nasal-cranial communicating tumors according to the site of tumor growth. The skull base tumors can be divided into midline skull base tumors, paramedian skull base tumors, and lateral skull base tumors according to the site of growth of the main body of the tumor. Nasal-cranial base tumors include tumors of various histologic origins, each with its own clinical, radiologic, and prognostic features. Depending on the tumor growth site and tissue type characteristics, choosing the appropriate treatment modality or surgical treatment approach can greatly help to improve the survival rate and quality of life of patients. In recent years, with the development of endoscopic and microsurgical techniques and various new therapeutic methods, such as new radiotherapy, targeted therapy, and immunotherapy, the treatment effect of various types of nasal-skull base tumors has been improved to some extent, but tumor recurrence and metastasis are still the main reasons for treatment failure of nasal-skull base tumors. Therefore, research on the diagnosis and treatment of recurrent and metastatic tumors is more important. In addition, multi-omic basic research on each tissue type of tumor provides novel targeted agents for tumor types that are not sensitive to existing treatments. At the same time, various clinical cohort studies for the treatment of recurrent metastatic tumors provide a basis for selecting the most suitable treatment regimen that will improve medical efficiency and improve patient survival and quality of life after treatment while minimizing patient suffering.

The aim of this study is to summarize the progress of diagnosis and treatment of recurrent nasal-skull base tumors, focusing on the diagnosis of recurrent tumors, the selection of endoscopic, microscopic, and open surgical approaches, the application of post-surgical repair techniques, and the application of integrated treatments such as radiotherapy, chemotherapy, targeted therapy and immunotherapy in different stages of recurrent tumors. We hope that the authors will share their clinical experience and translational results of basic research and clinical care, which will provide guidance and future directions for the treatment of recurrent and metastatic nasal-skull base tumors.

We welcome Original Research, Reviews, Mini-reviews, and Case Series on recurrent and metastatic nasal-skull base tumors. Topics include and are not limited to:
• Surgical partitioning and surgical access selection for recurrent nasal-skull base tumors.
• New surgical procedures for recurrent nasal-skull base tumors.
• Experience in the management of internal carotid artery in the surgical treatment of recurrent nasal-cranial base tumors.
• Postoperative repair of nasal-cranial base tumor and postoperative complication prevention and treatment.
• The quality of survival management and evaluation after treatment of nasal-skull base tumor.


Please note that manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in Frontiers in Oncology.