The pathogenesis of glomerular diseases are considered to be the result of interplay between genetics and unfavourable environmental conditions. Here, genetic factors may predispose certain individuals to develop immune responses that can lead to glomerulonephritis and inflammatory and non-inflammatory immune mechanisms are involved in this pathogenesis of glomerular injury. A kidney biopsy is typically required to establish diagnosis in patients with suspected glomerular disease, assess prognosis and plan therapy in short and long term. Recent advances in the pathogenesis of primary and secondary glomerular diseases, including lupus nephritis and pauci-immune glomerulonephritis, bring into light new treatment options opening new roads in the management of these disorders.
In this Research Topic we aim to describe current and new insights regarding the pathogenesis of primary glomerular diseases as well as secondary ones, i.e. lupus nephritis and pauci-immune glomerulonephritis, in order to highlight all new uncovered pathways, which will result in introducing the use of new therapeutic options in the field. Results from the use of existing or innovative therapies in clinical practice are also of interest. With each disease entity, we will also aim to present a pragmatic approach to diagnosis and treatment and highlight emerging therapies and future directions for research in that disease state.
Particular themes of interest include but are not limited to:
• IgA nephropathy
• Focal segmental glomerulosclerosis
• Membranous nephropathy
• Minimal change disease
• Fibrillary glomerulonephritis
• Membranoproliferative glomerulonephritis
• C3 glomerulonephritis
• Lupus nephritis
• Pauci-immune glomerulonephritis
The pathogenesis of glomerular diseases are considered to be the result of interplay between genetics and unfavourable environmental conditions. Here, genetic factors may predispose certain individuals to develop immune responses that can lead to glomerulonephritis and inflammatory and non-inflammatory immune mechanisms are involved in this pathogenesis of glomerular injury. A kidney biopsy is typically required to establish diagnosis in patients with suspected glomerular disease, assess prognosis and plan therapy in short and long term. Recent advances in the pathogenesis of primary and secondary glomerular diseases, including lupus nephritis and pauci-immune glomerulonephritis, bring into light new treatment options opening new roads in the management of these disorders.
In this Research Topic we aim to describe current and new insights regarding the pathogenesis of primary glomerular diseases as well as secondary ones, i.e. lupus nephritis and pauci-immune glomerulonephritis, in order to highlight all new uncovered pathways, which will result in introducing the use of new therapeutic options in the field. Results from the use of existing or innovative therapies in clinical practice are also of interest. With each disease entity, we will also aim to present a pragmatic approach to diagnosis and treatment and highlight emerging therapies and future directions for research in that disease state.
Particular themes of interest include but are not limited to:
• IgA nephropathy
• Focal segmental glomerulosclerosis
• Membranous nephropathy
• Minimal change disease
• Fibrillary glomerulonephritis
• Membranoproliferative glomerulonephritis
• C3 glomerulonephritis
• Lupus nephritis
• Pauci-immune glomerulonephritis