Research Topic

Fungal diagnostics: culture, molecular, mass spectrometry

About this Research Topic

Invasive fungal diseases (IFDs) are a growing threat to human health, affecting more than 150 million people and taking 1.5 million lives per year. Incidence continues to rise owing to a growing population with an altered immune system, cancer, organ transplantation, and aging. Early and accurate diagnosis is crucial to enable early treatment and optimum patient outcomes.

Culture, microscopy, histopathological examination have been the “gold standard” for mycological diagnosis, but these decade-old methods have limited sensitivity and prolonged time to diagnosis. Immunochromatography technologies have ushered a new era of point-of-care diagnostics for Aspergillus, Cryptoccocus, and Histoplasma infections. Other non-culture-based approaches using molecular amplification methods, DNA barcoding, non-bias next generation sequencing, and mass spectrometry offer advantages in speed, accuracy, and the ability to identify fungi to the species level. Whilst considerable progress has been made, these technologies are not ready to replace conventional microscopy and culture yet. There are many technical challenges to overcome to improve accuracy of detection and ease of use. Further work is needed to ensure that these technologies are standardized, are scaled to routine clinical use, and are optimized for appropriate clinical settings. This Research Topic will focus on emerging and innovative approaches to improve the diagnosis of IFDs and vision for implementing these technologies. We cordially invite researchers to submit their work.


Keywords: Fungal diagnostics, Fungal culture, Mass Spectrometry


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Invasive fungal diseases (IFDs) are a growing threat to human health, affecting more than 150 million people and taking 1.5 million lives per year. Incidence continues to rise owing to a growing population with an altered immune system, cancer, organ transplantation, and aging. Early and accurate diagnosis is crucial to enable early treatment and optimum patient outcomes.

Culture, microscopy, histopathological examination have been the “gold standard” for mycological diagnosis, but these decade-old methods have limited sensitivity and prolonged time to diagnosis. Immunochromatography technologies have ushered a new era of point-of-care diagnostics for Aspergillus, Cryptoccocus, and Histoplasma infections. Other non-culture-based approaches using molecular amplification methods, DNA barcoding, non-bias next generation sequencing, and mass spectrometry offer advantages in speed, accuracy, and the ability to identify fungi to the species level. Whilst considerable progress has been made, these technologies are not ready to replace conventional microscopy and culture yet. There are many technical challenges to overcome to improve accuracy of detection and ease of use. Further work is needed to ensure that these technologies are standardized, are scaled to routine clinical use, and are optimized for appropriate clinical settings. This Research Topic will focus on emerging and innovative approaches to improve the diagnosis of IFDs and vision for implementing these technologies. We cordially invite researchers to submit their work.


Keywords: Fungal diagnostics, Fungal culture, Mass Spectrometry


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

04 July 2021 Abstract
27 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

04 July 2021 Abstract
27 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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