About this Research Topic
Although new representative species are isolated and identified every day, perhaps no other model system is more well-characterized than bacteriophages (phages). Phages have provided a framework for how to understand other, more complex virological systems and hold much promise for the serious pharmaceutical challenges that continue to confront clinicians. Three exciting areas of modern translational bacteriophage research include nanoparticles for gene delivery, tools for disease diagnosis, and therapy for multi-drug resistant bacterial infections. Bacteriophage gene delivery and theranostics, where targeted identification and destruction of an infecting agent is achieved concurrently, have inherent advantages and disadvantages. The major disadvantage of phage platforms for treatment and theranostics is the lack of published evidence-based efficacy and safety data and the resulting lack of licensed approval by governmental health care safety and regulatory agencies.
The major disadvantage of platforms for bacteriophage-mediated treatment and theranostics is the lack of published evidence-based efficacy and safety data, and the resulting lack of licensed approval by governmental health care safety and regulatory agencies. The goals of this effort are to provide a platform for the dissemination of evidence-based efficacy, innovative methodology, and creative approaches for utilizing phage in the clinical setting, and to bring together cross-disciplinary expertise to further the use of phage for translational medicine.
The scope of this research topic includes, but is not limited to clinically relevant phage discovery/characterization, innovative methods for use of well-characterized phage for detection, diagnosis, or treatment of disease. The development of phage as platforms for the identification and destruction of diseased cells such as tumors. Phage nanoparticles, pseudo particles, or phage protein cages as vehicles for therapeutic delivery. Structural studies that characterize phage toxins, for cancer treatment are also of interest. We are soliciting primary research articles, review articles, clinical trials, evidence-based systematic reviews and meta-analyses, and case studies.
Keywords: Bacteriophages, Phages, Gene-Delivery, Diagnosis, Nanoparticles, Therapy, Diagnostics, Theranostics
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