About this Research Topic
The human skin protects internal organs as a physical/chemical barrier from environmental stress and dehydration. Nevertheless, the skin is the most wound-susceptible organ in the human body, requiring appropriate protection from pathogens and other infections. Significant efforts have been made to develop non-toxic, antibiotic and biocompatible substances and materials for wound healing applications. The antibacterial activity of these materials can play a crucial role, since most wounds can get infected by bacteria. Metal nanoparticles have significant antibacterial properties, rendering them promising agents towards the inhibition of bacterial growth. Therefore, it is essential to develop metal nanoparticle-based antibacterial materials for wound healing applications by using modern nanotechnology approaches.
Globally, around 8.2 million people suffer wounds with or without infections. The total global healthcare cost for wound treatment is currently $28.1 billion and a 6% increase is projected by 2025. Chronic wounds are estimated to increase worldwide as a type of lifestyle disease, similar to the increase of diabetes, obesity, and cardiovascular disease. Surgical site infections are serious operative complications occurring in approximately 2-5% of all surgical procedures, and account for some 20-30% of all healthcare-associated infections. Wound infections cause considerable patient morbidity. Chronic wounds can heal poorly and are susceptible to bacterial infections which interfere with wound closure and are challenging to manage, with potential poor clinical outcomes, including limb amputations and death. Infected wounds are treated systemically with antibiotics but topical management using antibacterial wound dressings could accelerate healing by releasing bioactive molecules that kill bacteria and promote favorable conditions for wound closure. The aim of this Research Topic is to highlight the nanotechnology advances towards developing such materials for effective wound healing applications
We invite the submission of Original Research, Reviews, Mini-Reviews and Perspective articles on nano-scale materials with potential wound-healing application, including (but not limited to):
- Polymer/biopolymer-stabilized metal nanoparticles
- Nanocomposite materials (eg. gels, films, gauzes, foams, hydrogels, beads, patches, etc.)
- Materials with antibiotic properties
- Materials with antibacterial properties
- Antibacterial textile fibers.
Keywords: Polymer, Biopolymers, Metal nanoparticles, Antibacterial property, Nanocomposites, Biomedical applications
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