About this Research Topic
Asthma is a complex respiratory disease involving different phenotypes that are under the influence of genetic and environmental factors. These factors trigger multifactorial signals between the immune system and lung parenchymal cells ultimately govern clinical signs and symptoms responsible for different asthma phenotypes/endotypes. The use of animal models to reproduce the similarities of the various molecular and physiological manifestations such as early life influences and asthma exacerbations are of importance. The integration of data from in vitro and in vivo models together with use of new insights raised from genetic and transcriptomic studies and computational techniques in man and animals has allowed validation of the pathophysiology of airway allergy and remodeling, also improving the predictive accuracy and translation of novel therapeutic candidates for the many asthma endotypes.
This Research Topic aims to shed some light on our current understanding of human asthma phenotypes/endotypes and therapeutics. We welcome the submission of Original Research articles, Reviews, and Mini-Reviews, which cover the underlying immunological mechanisms of asthma endotypes obtained from animal models and clinical studies, but are not limited to, the following topics of interest:
-In vivo models of studies involving epigenetics, immunogenicity of proteins/allergens; impairment/gain in function of proteins and specific tissue cell lines related; sensitization and allergy based on new adjuvants; lung and gut microbiota; models of comorbidities related to asthma manifestations, such as exposure to cigarette smoke, bacterial and viral infections; pre-clinical studies of drug candidates; and limitations of using murine models
-In vitro models of airway allergy using lung organoids, the study of cell biology of epithelial, endothelial and smooth muscle cells, pericyte, fibroblasts, leukocytes resident or migrated from circulation/lymphoid organs.
-In silico models to understand the human asthma phenotypes.
Keywords: Asthma, Airway inflammation, Mucosal immunology, Airway hyperresponsiveness, Allergy, Airway remodeling
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