Research Topic

Ion Channels and Transporters in Epilepsy: From Genes and Mechanisms to Disease-Targeted Therapies

About this Research Topic

Ion channels and transporters are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. In recent years, many breakthroughs have been made in identifying different mutated ion channel genes linked to epilepsy. The genetic basis of these ...

Ion channels and transporters are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. In recent years, many breakthroughs have been made in identifying different mutated ion channel genes linked to epilepsy. The genetic basis of these channelopathies provides a unique opportunity to investigate their underlying mechanisms from the molecular to whole-organism levels and has brought new molecular players as further potential therapeutic targets. At the state-of-the-art, patients afflicted by these genetic epilepsies mostly rely on “symptomatic” approaches that mitigate seizures and other major symptoms but do not target the underlying physiological causes of the disease. Gaining a detailed understanding of the regulation of ion transport as well as its disease-associated alterations will be key to the development of new therapeutic approaches against genetic epilepsies.

In this Research Topic, we are aiming to broadly address the molecular mechanisms and the current standing and progress, as well as novel channelopathy treatment approaches related to ion channels and transporters, with regard to epilepsy. We welcome all original research papers and review submissions on, but not limited to, the following themes:
- Candidate ion channel or transporter gene analysis on genetic epilepsy.
- Studies on novel cellular and molecular mechanism which has potential pharmacological translational significance.
- Investigating large and well-characterized patient cohorts which bring novel insights into epileptic channelopathies.
- Investigating potential novel therapeutic approaches to channelopathies in epilepsy, such as bioactive molecules and nutraceutical, iPS cells and organoids.

Contributions from leading international investigators will guarantee a broad and comprehensive understanding of the molecular basis underlying genetic epilepsy caused by mutations in ion channels and transporters, as well as related clinical problems. We hope that you will find it of interest and submit your valuable research.


Keywords: Ion Channels, Ion Transporters, Epilepsy, Genetic, Channelopathy


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

05 November 2021 Manuscript
30 November 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

05 November 2021 Manuscript
30 November 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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