About this Research Topic
Stroke is a common and devastating neurological disorder, which is associated with high mortality and morbidity. Besides the primary ischemic or hemorrhagic brain injury caused by stroke, neuroinflammation develops responding to various post-stroke ictus stimuli. Disintegrated cell components initiate innate inflammatory process via activating microglia, astrocytes, and even pericytes which lead to the release of proinflammatory cytokines and chemokines to further attract the infiltration of peripheral immune cells. Recent advances in our understanding of the pathogenesis of neuroinflammation after stroke have facilitated the identification of novel therapeutic targets that attenuate detrimental pro-inflammatory responses and promote beneficial repair responses in the brain. In addition, the regulation of brain-peripheral immune crosstalk is another important strategy in the management of post-stroke neuroinflammation.
The goal of this Research Topic is to compile a series of articles aiming at identifying, treating, and modulating neuroinflammation and brain-peripheral immune crosstalk after stroke. It is with a view to improve our understanding and enhance the development of cutting-edge therapeutic strategies. We welcome submissions of Reviews, Mini Reviews, Original Research articles, Case Reports and Clinical Trials that cover, but are not limited to, the following sub-topics:
1. The role of innate immunity and metabolism in the pathogenesis of post-stroke neuroinflammation .
2. Different functions of the neuroinflammation in the acute and chronic phases of stroke.
3. Role of immune-glial cells interaction in the blood-brain barrier disruption and dysfunction after stroke, including infiltrating monocytes, microglia, astrocytes and pericytes.
4. The influence of peripheral factors such as microbiota and cytokines on the neuromodulation and neuroinflammation
5. Mechanisms underlying the dysfunctions of peripheral organs and the post-stroke brain-peripheral crosstalk involving brain-spleen axis, neurogenic lung diseases, cerebro-cardiac syndrome, etc.
6. Novel diagnosis or management strategies of post-stroke neuroinflammation.
Keywords: Neuroinflammation, Brain-Peripheral Crosstalk, Stroke, Blood Brain Barrier, Metabolism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.