Molecular Markers and Targeted Therapy for Hepatobiliary Tumors

216.9K

views

412

authors

52

articles

Molecular Markers and Targeted Therapy for Hepatobiliary Tumors

216.9K

views

412

authors

52

articles

Editors

0

Impact

Fetching...

About

Download the ebooks for this Research Topic:

Volume I.A:
PDF ¦ EPUB
Volume I.B:
PDF ¦ EPUB

Hepatobiliary tumor, mainly including hepatocellular carcinoma, cholangiocarcinoma and gallbladder cancer, is a group of highly aggressive malignancies. Hepatocellular carcinoma, cholangiocarcinoma and gallbladder cancer have different biological characters, histopathological traits, and treatment strategies, but have similar clinical features such as silent early symptom and extremely poor prognosis. The diagnostic, predictive or prognostic tumor biomarkers of hepatobiliary cancers are in unmet need. In contrast to the poor outcome, the treatment options to hepatobiliary cancers are very limited. It is still controversial about the effects of chemotherapy and radiotherapy of hepatobiliary cancer. FDA-approved targeted drugs are only Sorafenib and Lenvatinib for hepatocellular carcinoma, and Pemigatinib for cholangiocarcinoma. Unfortunately, these drugs are only effective for 5%-30% patients. Therefore, more attention should be called upon on investigating effective biomarkers and drug targets, stratifying high-risk patients, guiding precise treatments, and developing therapeutic strategies for hepatobiliary cancers.

This Research Topic aims at discussing the current knowledge and proceedings of diagnostic, predictive and prognostic tumor biomarkers in hepatobiliary cancer, and presenting the recent advances on new drug targets and potential targeted therapies of hepatobiliary cancer.

We welcome submissions of Review, Mini-Review, Clinical Trial and Original Research articles covering, but not limited to, the following topics:

1. new diagnostic/prognostic factors, biomarkers and/or risk factors in hepatobiliary tumors
2. new drug targets, and oncogenic or tumor suppressive molecular mechanism of the novel targets
3. new intervention or targeted therapy in hepatobiliary tumors
4. new findings of bioinformatics or high-throughput methods such as mass spectrometry and genome-wide association studies or which may help screen the potential biomarkers of hepatobiliary tumors
5. clinical studies such as cohort study or RCT to identify new risks or treatment therapies in hepatobiliary tumors
6. basic, pharmacological, preclinical or clinical study of potential drugs targeting hepatobiliary tumors

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.

Download the ebooks for this Research Topic:

Volume I.A:
PDF ¦ EPUB
Volume I.B:
PDF ¦ EPUB

Hepatobiliary tumor, mainly including hepatocellular carcinoma, cholangiocarcinoma and gallbladder cancer, is a group of highly aggressive malignancies. Hepatocellular carcinoma, cholangiocarcinoma and gallbladder cancer have different biological characters, histopathological traits, and treatment strategies, but have similar clinical features such as silent early symptom and extremely poor prognosis. The diagnostic, predictive or prognostic tumor biomarkers of hepatobiliary cancers are in unmet need. In contrast to the poor outcome, the treatment options to hepatobiliary cancers are very limited. It is still controversial about the effects of chemotherapy and radiotherapy of hepatobiliary cancer. FDA-approved targeted drugs are only Sorafenib and Lenvatinib for hepatocellular carcinoma, and Pemigatinib for cholangiocarcinoma. Unfortunately, these drugs are only effective for 5%-30% patients. Therefore, more attention should be called upon on investigating effective biomarkers and drug targets, stratifying high-risk patients, guiding precise treatments, and developing therapeutic strategies for hepatobiliary cancers.

This Research Topic aims at discussing the current knowledge and proceedings of diagnostic, predictive and prognostic tumor biomarkers in hepatobiliary cancer, and presenting the recent advances on new drug targets and potential targeted therapies of hepatobiliary cancer.

We welcome submissions of Review, Mini-Review, Clinical Trial and Original Research articles covering, but not limited to, the following topics:

1. new diagnostic/prognostic factors, biomarkers and/or risk factors in hepatobiliary tumors
2. new drug targets, and oncogenic or tumor suppressive molecular mechanism of the novel targets
3. new intervention or targeted therapy in hepatobiliary tumors
4. new findings of bioinformatics or high-throughput methods such as mass spectrometry and genome-wide association studies or which may help screen the potential biomarkers of hepatobiliary tumors
5. clinical studies such as cohort study or RCT to identify new risks or treatment therapies in hepatobiliary tumors
6. basic, pharmacological, preclinical or clinical study of potential drugs targeting hepatobiliary tumors

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.

Download ebook

Share

Editors

Impact

216,869 Total views

135,876 Article views

76,308 Article downloads

4,685 Topic views

Published In

Journal Thumbnail

Frontiers in Oncology

Cancer Molecular Targets and Therapeutics

Journal Thumbnail

Frontiers in Pharmacology

Cancer Molecular Targets and Therapeutics

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic