About this Research Topic
Epigenetics has accelerated rapidly and reflected more and more advances in the understanding of biology, which closely impacted the physiology and function of the system in combination with genetic and environmental factors. Signals, such as transcription factors, non-coding RNAs, DNA methylation, histone modifications and RNA modifications, all contributed to the regulatory plasticity and stable heritability and finally resulted in a complex state of epigenetics. Mutations in epigenetic components occur during development, in response to physiological stimuli, and other human diseases. More than a decade ago, some studies have reported that inherited and/or acquired epigenetic features may increase susceptibility and lead to the occurrence of intestinal diseases, such as inflammatory bowel disease (IBD) and irritable Bowel Syndrome (IBS). Many laboratories have worked on the problem, but the structural and molecular basis of epigenetic programming in intestinal diseases have not been described in detail.
This Research Topic aims to provide an overview of the current advances in the understanding of epigenetic control in intestinal disease, which includes DNA methylation, RNA methylation, histone modifications, and even intestinal microbiota. Recent advances in nutritional regulation strategies for intestinal diseases will also be discussed.
This Research Topic welcomes, but is not limited to, the following themes:
-The epigenetic mechanism of intestinal disease, including IBD, IBS, gut dysbiosis and other intestinal diseases.
-The innovative approaches and ideas aimed to integrate epigenetics and intestinal disease research.
-The exploration of novel epigenetics-related nutrients that could regulate intestinal health.
Keywords: Epigenetics; Nutritional regulation; Intestinal Immune response; Intestinal disease; Inflammatory Bowel Disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
