Research Topic

Environmental Risk Factors in Autism Spectrum Disorder

About this Research Topic

Autism spectrum disorder (ASD) is a neurodevelopmental disease defined by attention deficits, social deficits, and repetitive behaviors. While it has been documented that various copy numbers or single nucleotide variations are associated with ASD, less examined at the multiple environmental factors (e.g., maternal infection exposure to drugs or toxicants, and brain inflammation). These factors, their interactions, and the resultant complex symptoms make therapeutic approaches challenging.

To address the therapeutic approaches in ASD, we aim to define the causal environmental factors in animal models and patients. In particular, we seek to answer the questions of how and what neuronal circuits are involved in each symptom including attention deficits, social deficits, and repetitive behaviors. We also discuss the various copy number or single nucleotide variations associated with ASD in human or animal models. The goal of the Research Topic is to discover the novel therapeutic targets by definition of the common pathways and common environmental risks in human and animal models.

We invite the following themes to this Research Topic:

• Environmental risk factors in autism spectrum disorder (ASD)
• Common features between animal models and patients in ASD
• Novel therapeutic approach in ASD
• Development of diagnostic strategies for ASD


Keywords: environmental risk factors, autism spectrum disorder, approaches, neurodevelopmental disorder diagnosis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Autism spectrum disorder (ASD) is a neurodevelopmental disease defined by attention deficits, social deficits, and repetitive behaviors. While it has been documented that various copy numbers or single nucleotide variations are associated with ASD, less examined at the multiple environmental factors (e.g., maternal infection exposure to drugs or toxicants, and brain inflammation). These factors, their interactions, and the resultant complex symptoms make therapeutic approaches challenging.

To address the therapeutic approaches in ASD, we aim to define the causal environmental factors in animal models and patients. In particular, we seek to answer the questions of how and what neuronal circuits are involved in each symptom including attention deficits, social deficits, and repetitive behaviors. We also discuss the various copy number or single nucleotide variations associated with ASD in human or animal models. The goal of the Research Topic is to discover the novel therapeutic targets by definition of the common pathways and common environmental risks in human and animal models.

We invite the following themes to this Research Topic:

• Environmental risk factors in autism spectrum disorder (ASD)
• Common features between animal models and patients in ASD
• Novel therapeutic approach in ASD
• Development of diagnostic strategies for ASD


Keywords: environmental risk factors, autism spectrum disorder, approaches, neurodevelopmental disorder diagnosis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

06 November 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

06 November 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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