Research Topic

Small RNAs in Viral Infection and Host Immune Response

About this Research Topic

Innate immune responses are triggered immediately after viral infection by mechanisms that have been evolutionarily conserved across diverse eukaryotes. Small RNAs, including small interfering RNAs (siRNAs), microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs), are 20-30 nt in length and all direct the formation of RNA-induced silencing complex (RISC) to guide sequence-specific gene mRNA silencing (siRNA) or inhibition of mRNA translation (miRNA). This process is known as RNA interference (RNAi) and involves regulating viral propagation and pathogenesis, which can confer cell-intrinsic antiviral activity. In response, viruses that infect plants, insect and mammals have evolved multiple strategies to suppress RNAi or manipulate host gene expression by utilizing small RNA.

In this Research Topic, we will incorporate the most recent findings on uncovering the physiological roles of small RNAs, including siRNAs, miRNAs and piRNAs, on viral infection and pathogenesis, and viral immune evasion mechanisms for small RNA-based immunity.

We welcome all perspective articles, including Original Research Article, Review, Mini review and Hypothesis, Theory, etc. This Research Topic can address the following themes but not limited to:
• Uncover the alternations of small RNAs, including miRNAs, piRNAs and viral siRNAs, in response to viral infection.
• The physiological roles of small RNAs on viral infection and pathogenesis.
• Virus utilizes small RNAs and/or RNAi to manipulate viral or host gene expression for effective propagation.
• Viruses suppress antiviral RNAi.
• Develop novel antivirals by targeting the RNAi pathway or small RNAs.


Keywords: siRNA, miRNA, piRNA, RNAi, antiviral RNAi, host-virus interaction, viral immune evasion for small-RNA based immunity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Innate immune responses are triggered immediately after viral infection by mechanisms that have been evolutionarily conserved across diverse eukaryotes. Small RNAs, including small interfering RNAs (siRNAs), microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs), are 20-30 nt in length and all direct the formation of RNA-induced silencing complex (RISC) to guide sequence-specific gene mRNA silencing (siRNA) or inhibition of mRNA translation (miRNA). This process is known as RNA interference (RNAi) and involves regulating viral propagation and pathogenesis, which can confer cell-intrinsic antiviral activity. In response, viruses that infect plants, insect and mammals have evolved multiple strategies to suppress RNAi or manipulate host gene expression by utilizing small RNA.

In this Research Topic, we will incorporate the most recent findings on uncovering the physiological roles of small RNAs, including siRNAs, miRNAs and piRNAs, on viral infection and pathogenesis, and viral immune evasion mechanisms for small RNA-based immunity.

We welcome all perspective articles, including Original Research Article, Review, Mini review and Hypothesis, Theory, etc. This Research Topic can address the following themes but not limited to:
• Uncover the alternations of small RNAs, including miRNAs, piRNAs and viral siRNAs, in response to viral infection.
• The physiological roles of small RNAs on viral infection and pathogenesis.
• Virus utilizes small RNAs and/or RNAi to manipulate viral or host gene expression for effective propagation.
• Viruses suppress antiviral RNAi.
• Develop novel antivirals by targeting the RNAi pathway or small RNAs.


Keywords: siRNA, miRNA, piRNA, RNAi, antiviral RNAi, host-virus interaction, viral immune evasion for small-RNA based immunity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 September 2021 Abstract
31 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 September 2021 Abstract
31 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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