Research Topic

The analgesic effect of biphalin & its analogues in acute and chronic pain

About this Research Topic

Biphalin is a dimeric peptide [(Tyr-D-Ala-Gly-Phe-NH–)2] in which two enkephalin type
pharmacophores are connected "head-to-head" by a hydrazide bridge. It has a high, nearly equal affinity for both μ and δ opioid receptors, and a moderate affinity for κ opioid receptors.

As an opioid receptor agonist, Biphalin has been shown to have a marked analgesic effect against cancer pain, abdominal pain and neuropathic pain. For years researchers have developed new Biphalin analogues to improve blood-brain barrier penetration and efficiency for the analgesic profiles.

Biphalin has been shown to be a much more potent analgesic than either morphine or etorphine. However, coupled with new interest in "opioids join hands", there is increasing focus on the combination of these opioids and the therapeutic strategy in the treatment of acute and chronic pain.

The goal of this research topic is to bring together a collection of papers that further elucidate the mechanistic pharmacology of Biphalin & its analogues in acute and chronic pain.

We welcome the submission of manuscripts including, but not limited to, the following topics:
1. Biphalin efficacy for peripheral neuropathic pain.
2. Identification of the anti-nociceptive role of Biphalin in acute pain (e.g. CFA, acetic acid and
capsicin-induced).
3. Biphalin combined with other opioids - strategy for treatment of acute and chronic pain.
4. Biphalin analogues, routes of administration and pharmacokinetic-pharmacodynamic
relationships in treatment of acute and chronic pain.


Keywords: Biphalin, Analogues, Opioid receptors, acute pain, neuropathic pain


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Biphalin is a dimeric peptide [(Tyr-D-Ala-Gly-Phe-NH–)2] in which two enkephalin type
pharmacophores are connected "head-to-head" by a hydrazide bridge. It has a high, nearly equal affinity for both μ and δ opioid receptors, and a moderate affinity for κ opioid receptors.

As an opioid receptor agonist, Biphalin has been shown to have a marked analgesic effect against cancer pain, abdominal pain and neuropathic pain. For years researchers have developed new Biphalin analogues to improve blood-brain barrier penetration and efficiency for the analgesic profiles.

Biphalin has been shown to be a much more potent analgesic than either morphine or etorphine. However, coupled with new interest in "opioids join hands", there is increasing focus on the combination of these opioids and the therapeutic strategy in the treatment of acute and chronic pain.

The goal of this research topic is to bring together a collection of papers that further elucidate the mechanistic pharmacology of Biphalin & its analogues in acute and chronic pain.

We welcome the submission of manuscripts including, but not limited to, the following topics:
1. Biphalin efficacy for peripheral neuropathic pain.
2. Identification of the anti-nociceptive role of Biphalin in acute pain (e.g. CFA, acetic acid and
capsicin-induced).
3. Biphalin combined with other opioids - strategy for treatment of acute and chronic pain.
4. Biphalin analogues, routes of administration and pharmacokinetic-pharmacodynamic
relationships in treatment of acute and chronic pain.


Keywords: Biphalin, Analogues, Opioid receptors, acute pain, neuropathic pain


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

08 August 2021 Abstract
06 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

08 August 2021 Abstract
06 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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