Research Topic

Functions of noncoding RNA in Innate Immunity

  • Submission closed.

About this Research Topic

The innate immune system is the first line of defense against invading pathogens. Activation of the innate immune signaling pathways is a highly complex process resulting in the induction of inflammatory gene expression that is central to anti-microbial defenses. Initiation of the response typically occurs at ...

The innate immune system is the first line of defense against invading pathogens. Activation of the innate immune signaling pathways is a highly complex process resulting in the induction of inflammatory gene expression that is central to anti-microbial defenses. Initiation of the response typically occurs at the level of pathogen recognition receptors (PRRs) such as the Toll like receptors (TLRs), triggering a signaling cascade resulting in the activation of transcription factors such as NFB and IRFs. Many factors are required to control these responses and in recent years it has been shown that noncoding RNA are major contributors to the control of gene expression within innate immunity.
Recent advances in sequencing technologies has enabled us to get a much greater view of the genome and surprisingly it appears that only 2% of the genome codes for protein while it is estimated that 85% of the genome gets transcribed. Much of this transcription results in the production of noncoding RNA including miRNA and the more recently described long noncoding RNA. Much work has been done to show that miRNA are key regulators of the innate immune system and this year alone there has been a number of key papers showing that long noncoding RNA are also essential mediators of the immune response. I propose to have a comprehensive specialist topic covering the roles that noncoding RNA play in innate immunity. I believe this is a field that is in its infancy, which is generating much excitement and this topic within Frontiers will be of much interest to all people involved in the study of innate immunity.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top