About this Research Topic
The development of new principles for drug release control is increasingly associated with the use of nanocomposite materials. At the same time, the provision of controlled release of drugs largely determines the effectiveness of the use of dosage forms, allowing fine tuning in order to optimize and prolong the therapeutic effect while minimizing toxicity. Nanoparticles represent a promising carrier of drugs, often providing a high capacity for an immobilized drug and its physiological availability. Hydrogels largely mimic the tissues of a living organism and often have high biocompatibility, which makes them attractive for soft tissue replacement and filling of postoperative cavities. Therefore, a significant effect can be expected from the combination of the achievements of nanotechnology and hydrogel technology as applied to the problems of therapy for a wide range of diseases, including oncological ones.
The development of methods for the preparation of nanocomposites based on hydrogels is an important task that opens an approach to the creation of a new generation of materials for biomedical purposes. Also, nanocomposites of hydrogels are of interest for the sorption separation of mixtures, purification, isolation of substances, and other applications. Methods for the synthesis of nanocomposites based on hydrogels are diverse and intensively developed, including polymerization filling and Incorporation of nanoparticles into polymers. Optimization of preparation conditions, development of new synthetic methods and approaches to the inclusion of medicinal substances, regulation of sorption properties are the priority tasks that determine the success of the use of nanocomposites based on hydrogels. The search for new areas of application of nanomaterials based on hydrogels is also a major task, since the applied potential of these composites is just beginning to unfold. Of particular interest is the quantitative modeling of the processes of binding and release of various substances by nanocomposites based on hydrogels.
This Research Topic is aimed at achieving maximum information coverage on the synthesis, study of the properties and application of nanomaterials based on hydrogels. Priority will be given to manuscripts on the following areas:
- Immobilization of biologically active substances on nanoparticles for their subsequent use in the synthesis of nanocomposites based on hydrogels;
-Physical chemistry of mass transfer and sorption processes with the participation of nanocomposites based on hydrogels;
- Synthesis and development of nanocomposites based on hydrogels;
- Optimization and computer modeling of nanocomposites based on hydrogels;
- Analysis of the profiles of binding and release of substances, including physiologically active ones, in systems containing nanocomposites based on hydrogels;
- Engineering and economic aspects of the use of nanocomposites based on hydrogels.
The listed directions do not exhaust the range of issues and topics of manuscripts that may be of interest for this Research Topic.
Keywords: Substance Immobilization, Substance Binding, Substance Release, Nanoparticles, Nanocomposites, Hydrogels, Mass Transfer, Sorption Process, Nanocomposites Computer Modeling
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